D25AC00432
Cooperative Agreement
Overview
Grant Description
We aim to develop a scalable patient specific bioprinted liver using iPSCs.
This liver will be tailored to a patient's unique anatomy and physiology without the need for donor tissue or immunosuppressants, ensuring long-term functionality and integration.
Upon successful completion of this project, we will establish a reliable on-demand source of functional liver tissues, potentially saving the lives of thousands of patients in the U.S. each year who either die on the waitlist or become too sick for a liver transplant due to a shortage of donor organs.
By leveraging iPSCs, the risk of organ rejection after implantation will be greatly reduced and the need for immunosuppression eliminated, significantly improving the quality and length of life for patients with liver failure.
This approach will also reduce the economic burden associated with liver transplantation and post-operative care.
This liver will be tailored to a patient's unique anatomy and physiology without the need for donor tissue or immunosuppressants, ensuring long-term functionality and integration.
Upon successful completion of this project, we will establish a reliable on-demand source of functional liver tissues, potentially saving the lives of thousands of patients in the U.S. each year who either die on the waitlist or become too sick for a liver transplant due to a shortage of donor organs.
By leveraging iPSCs, the risk of organ rejection after implantation will be greatly reduced and the need for immunosuppression eliminated, significantly improving the quality and length of life for patients with liver failure.
This approach will also reduce the economic burden associated with liver transplantation and post-operative care.
Funding Goals
SIGNIFICANT HEALTH IMPACT FOR THE FUTUREOF ORGAN TRANSPLANTATION AND PAVE THE WAY FOR THE NECESSARY NEXT STEPS IN SCALING TISSUE AND ORGANENGINEERING.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
California
United States
Geographic Scope
State-Wide
Related Opportunity
D-AQD-FA-25-013
San Diego University Of California was awarded
Patient-Specific Bioprinted Liver from iPSCs for On-Demand Transplants
Cooperative Agreement D25AC00432
worth $18,332,570
from Interior Business Center in September 2025 with work to be completed primarily in California United States.
The grant
has a duration of 3 years and
was awarded through assistance program 93.384 ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H).
Status
(Ongoing)
Last Modified 11/13/25
Period of Performance
9/25/25
Start Date
9/24/28
End Date
Funding Split
$18.3M
Federal Obligation
$0.0
Non-Federal Obligation
$18.3M
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
D25AC00432
SAI Number
None
Award ID URI
None
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
140D04 IBC ACQ SVCS DIRECTORATE (00004)
Funding Office
140D04 IBC ACQ SVCS DIRECTORATE (00004)
Awardee UEI
UYTTZT6G9DT1
Awardee CAGE
50854
Performance District
CA-50
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Modified: 11/13/25