D25AC00432

WE AIM TO DEVELOP A SCALABLE PATIENT SPECIFIC BIOPRINTED LIVER USING IPSCS. THIS LIVERWILL BE TAILORED TO A PATIENTS UNIQUE ANATOMY AND PHYSIOLOGY WITHOUT THE NEED FOR DONOR TISSUEOR IMMUNOSUP PRESSANTS ENSURING LONGTERM FUNCTIONALITY AND INTEGRATION. UPON SUCCESSFULCOMPLETION OF THIS PROJECT WE WILL ESTABLISH A RELIABLE ONDEMAND SOURCE OF FUNCTIONAL LIVERTISSUES POTENTIALLY SAVING THE LIVES OF THOUSANDS OF PATIENTS IN THE U.S. EACH YEAR WHO EITHERDIE ON THE WAITLIST OR BECOME TOO SICK FOR A LIVER TRANSPLANT DUE TO A SHORTAGE OF DONOR ORGANS.BY LEVERAGING IPSCS THE RISK OF ORGAN REJECTION AFTER IMPLANTATION WILL BE GREATLY REDUCED ANDTHE NEED FOR IMMUNOSUPPRESSION ELIMINATED SIGNIFICANTLY IMPROVING THE QUALITY AND LENGTH OFLIFE FOR PATIENTS WITH LIVER FAILURE. THIS APPROACH WILL ALSO REDUCE THE ECONOMIC BURDENASSOCIATED WITH LIVER TRANSPLANTATION AND POST OPERATIVE CARE.

San Diego University Of California

SIGNIFICANT HEALTH IMPACT FOR THE FUTUREOF ORGAN TRANSPLANTATION AND PAVE THE WAY FOR THE NECESSARY NEXT STEPS IN SCALING TISSUE AND ORGANENGINEERING.

93.384 - ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)

Interior Business Center (IBC) [DOI]

California United States

State-Wide

D-AQD-FA-25-013