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D25AC00185

Cooperative Agreement

Overview

Grant Description
Healthcare is becoming increasingly digitally dependent resulting in an increased cybersecurity threat and an elevated risk for data and functionality loss.

The goal of CyberHealthIntelligence is to extend a previously DOE funded technology Common Weakness Enumerations (CWE) to create an intelligence CWE driven system.

This technology applied to the full ecosystem of connected things in healthcare and combined with novel orchestration and machine learning capabilities will dramatically improve cyber defenses for hospital systems.

The project will extend the CWE framework to healthcare using large language models (LLMs).

A secondary objective of this proposal is to explore novel prompting with the LLM to create a self-aware cybersecurity system.

These objectives will be achieved through completion of eight tasks.

Which includes the UTMDACC cybersecurity team to identify devices to be considered and automate the output of the device security information while using data collected for training of all the LLMs presented.

The Cybersecurity Manufacturing Innovation Institute of Texas at San Antonio (CYMANII) will train the first LLM on public data obtained.

The CYMANII team will train other LLM teams using public data and real domain specific data collected utilizing security event and incident management data along with historical data which will create a retrieval augmented generation (RAG) interface that can work with any of the LLMs.

It is anticipated that collection and curation of data will be ongoing as models are being trained and refined.

In total this proposed research is revolutionary because it represents a significant leap forward in the convergence of AI driven cybersecurity in healthcare.

The fundamental reality is that the sheer volume of cyber vulnerabilities cannot be addressed by current approaches.

The CWE approach coupled with a contextually aware LLM informed CYMANII Health Att CK Annex provides the ability to scale within the healthcare setting and continue to scale as this threat continues to evolve.

This revolutionary approach is necessary as one critical pillar to secure the healthcare institutions.
Funding Goals
THE FOUR INITIAL FOCUS AREAS ARE(1) HEALTH SCIENCE FUTURES(2) SCALABLE SOLUTIONS(3) PROACTIVE HEALTH(4) RESILIENT SYSTEMS
Awarding / Funding Agency
Place of Performance
Houston, Texas United States
Geographic Scope
City-Wide
Related Opportunity
D-AQD-FA-24-008
Analysis Notes
Amendment Since initial award the total obligations have increased 99% from $1,712,371 to $3,411,446.
The Univeristy Of Texas M.D. Anderson Cancer Center was awarded Revolutionizing Healthcare Cybersecurity with CWE-Driven Intelligence Cooperative Agreement D25AC00185 worth $3,411,446 from Interior Business Center in August 2025 with work to be completed primarily in Houston Texas United States. The grant has a duration of 2 years and was awarded through assistance program 93.384 ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H).

Status
(Ongoing)

Last Modified 11/13/25

Period of Performance
8/20/25
Start Date
8/19/27
End Date
12.0% Complete

Funding Split
$3.4M
Federal Obligation
$0.0
Non-Federal Obligation
$3.4M
Total Obligated
100.0% Federal Funding
0.0% Non-Federal Funding

Activity Timeline

Interactive chart of timeline of amendments to D25AC00185

Transaction History

Modifications to D25AC00185

Additional Detail

Award ID FAIN
D25AC00185
SAI Number
None
Award ID URI
None
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
140D04 IBC ACQ SVCS DIRECTORATE (00004)
Funding Office
140D04 IBC ACQ SVCS DIRECTORATE (00004)
Awardee UEI
S3GMKS8ELA16
Awardee CAGE
0KD38
Performance District
TX-09
Senators
John Cornyn
Ted Cruz
Modified: 11/13/25