D24AC00359

Our project aims to overcome a critical challenge in modern surgery: the precise differentiation of cancerous tissues from healthy ones without damaging vital structures.

We propose a cutting-edge camera and integrated clinical workflow that seamlessly fits into both open and laparoscopic surgical procedures.

This system will offer improved sensitivity and specificity for in vivo pathology at various scales, ensuring precise surgical margins and clear identification of critical anatomical structures.

Currently, surgical interventions are disrupted by the introduction of tools like drop-in ultrasound probes, which require halting the operation for image capture.

Our technology circumvents this by incorporating photoacoustic PA ultrasound (US) and fluorescence (FL) imaging into existing surgical endoscopes, allowing for real-time noncontact visualization.

This innovation is distinct in its holistic integration into surgical practice, providing real-time intraoperative imaging that highlights critical structures without disrupting the surgical process.

Over a 5-year ARPA-H program period, we plan to evolve from prototyping to preclinical testing in alignment with a structured development plan that includes feedback from end users.

Our interdisciplinary team from Johns Hopkins University, the University of Texas Southwestern, and the NIH Clinical Center, in partnership with industry leaders, is uniquely positioned to drive this innovation forward.

With a focus on reducing positive tumor margins and operative complications, our project aligns with the ARPA-H mission for precision surgery.

The Johns Hopkins University

THE FOUR INITIAL FOCUS AREAS ARE(1) HEALTH SCIENCE FUTURES(2) SCALABLE SOLUTIONS(3) PROACTIVE HEALTH(4) RESILIENT SYSTEMS

93.384 - ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)

Interior Business Center (IBC) [DOI]

Maryland United States

State-Wide

D-AQD-FA-24-023