C06OD036038
Project Grant
Overview
Grant Description
Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource - Abstract
The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) Rhesus Macaque colony of Indian origin (IND RM), supported by the NIH SPF Rhesus Breeding Program (U42OD010442), and a smaller SPF P51 supported colony.
We currently house ~1000 Rhesus Macaques, of which the U42 colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions.
However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF IND RM. This has severely impacted our ability to support the national and international research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc.
The NIH has recognized this need for expansion of SPF Rhesus production and strongly recommends increasing IND RM breeding capacity. The SNPRC is well positioned to expand its SPF IND RM production as a center located in a climate hospitable to largely outdoor housing, at an institution with capacity for expansion.
Our host institution, Texas Biomed, raised funds and is currently building new NHP facilities which will house ~600 NHPs. Texas Biomed/SNPRC has also been funded by the NIH/ORIP to expand our production capacity by 30% over our existing capacity via other mechanisms.
Finally, through Texas Biomed support, we have procured ~150 conventional founder/breeder IND RM. This founder colony has increased the number of breeding pairs the SNPRC macaque colony management team can generate, and it is expected that in the upcoming birthing season, ~200 RM live births will occur, double that of each of the last several years.
As such, the SNPRC IND RM population can increase to 1500+ in the next five years. Funded partially by this C06, we seek to construct an additional animal housing/breeding facility adjacent the two new holding/breeding facilities currently under construction, as part of the overall $45M long term animal care complex project.
This will further allow us to house, breed, and maintain an additional supply of ~300 IND RM for AIDS/emerging infectious diseases research.
The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) Rhesus Macaque colony of Indian origin (IND RM), supported by the NIH SPF Rhesus Breeding Program (U42OD010442), and a smaller SPF P51 supported colony.
We currently house ~1000 Rhesus Macaques, of which the U42 colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions.
However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF IND RM. This has severely impacted our ability to support the national and international research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc.
The NIH has recognized this need for expansion of SPF Rhesus production and strongly recommends increasing IND RM breeding capacity. The SNPRC is well positioned to expand its SPF IND RM production as a center located in a climate hospitable to largely outdoor housing, at an institution with capacity for expansion.
Our host institution, Texas Biomed, raised funds and is currently building new NHP facilities which will house ~600 NHPs. Texas Biomed/SNPRC has also been funded by the NIH/ORIP to expand our production capacity by 30% over our existing capacity via other mechanisms.
Finally, through Texas Biomed support, we have procured ~150 conventional founder/breeder IND RM. This founder colony has increased the number of breeding pairs the SNPRC macaque colony management team can generate, and it is expected that in the upcoming birthing season, ~200 RM live births will occur, double that of each of the last several years.
As such, the SNPRC IND RM population can increase to 1500+ in the next five years. Funded partially by this C06, we seek to construct an additional animal housing/breeding facility adjacent the two new holding/breeding facilities currently under construction, as part of the overall $45M long term animal care complex project.
This will further allow us to house, breed, and maintain an additional supply of ~300 IND RM for AIDS/emerging infectious diseases research.
Funding Goals
TO RENOVATE EXISTING RESEARCH FACILITIES AND BUILD NEW RESEARCH FACILITIES TO MEET BASIC AND CLINICAL SPACE REQUIREMENTS, LABORATORY SAFETY, BIOHAZARD CONTAINMENT, AND ANIMAL CARE STANDARDS IN ORDER TO SUPPORT THE FACILITY DEMANDS OF NIH RESEARCH PROGRAMS.
Grant Program (CFDA)
Awarding Agency
Place of Performance
Texas
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 100% from $4,000,000 to $8,000,000.
Texas Biomedical Research Institute was awarded
Expansion of SPF Rhesus Macaque Resource for HIV/AIDS Research
Project Grant C06OD036038
worth $8,000,000
from the National Institute of Allergy and Infectious Diseases in September 2023 with work to be completed primarily in Texas United States.
The grant
has a duration of 3 years 7 months and
was awarded through assistance program 93.352 Construction Support.
The Project Grant was awarded through grant opportunity Biomedical Research Facilities (C06 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 3/5/25
Period of Performance
9/8/23
Start Date
4/30/27
End Date
Funding Split
$8.0M
Federal Obligation
$0.0
Non-Federal Obligation
$8.0M
Total Obligated
Activity Timeline
Transaction History
Modifications to C06OD036038
Additional Detail
Award ID FAIN
C06OD036038
SAI Number
C06OD036038-230063601
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit With 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75AGNA NIH AGGREGATE FINANCIAL ASSISTANCE DATA AWARDING OFFICE
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
J4EYPCJDQ1H6
Awardee CAGE
02MD3
Performance District
TX-90
Senators
John Cornyn
Ted Cruz
Ted Cruz
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $8,000,000 | 100% |
Modified: 3/5/25