70NANB23H091

Purpose: The purpose of this project is to develop large public datasets from new sequencing technologies for public genomes from the Genome in a Bottle Consortium and NIST reference materials.

Activities to be performed: This proposal aims to generate high quality nanopore sequencing datasets required to characterize new tumor/normal cell lines that will likely become the first reference materials of their kind. Furthermore, the proposed transcriptome sequencing will further improve characterization and utility of the GIAB reference materials.

Expected outcomes: The proposed work will accomplish important objectives related to the NIST work on developing human genome reference materials and data. This work will provide important, public data for NIST's human genome reference materials that will be broadly useful to the community for bioinformatics and technology development, optimization, and demonstration, as well as clinical validation of genomic assays.

Intended beneficiaries: The technologies that are developed through this project could be applied to developing new genomics bioinformatics methods by academic and commercial laboratories, because these will be unique public data for broadly available human genomes. These fully public data for broadly consented samples would be the first of their kind for tumor and normal genomes.

Subrecipient activities: The recipient does not intend to subaward funds.

Northeastern University

TO SUPPORT ACTIVITIES THAT DEVELOP, EXPAND, STRENGTHEN, OR SUSTAIN NIST PARTNERSHIP PROGRAMS AND/OR SUPPORT THE CONDUCT OF RESEARCH OR A RECIPIENT'S PORTION OF COLLABORATIVE RESEARCH IN A VARIETY OF AREAS INCLUDING, BUT NOT LIMITED TO: METROLOGY; STANDARDS; NANOTECHNOLOGY; ARTIFICIAL INTELLIGENCE; ADVANCED COMMUNICATIONS; ADVANCED MANUFACTURING; PROMOTION OF U.S. INNOVATION AND INDUSTRIAL COMPETITIVENESS; MEASUREMENTS IN SCIENCES; NEUTRON RESEARCH; GREENHOUSE GAS MEASUREMENTS; AND ENHANCING COORDINATION OF THE U.S. STANDARDS SYSTEM WITH GOVERNMENT AND PRIVATE SECTOR ORGANIZATIONS.

11.609 - Measurement and Engineering Research and Standards

National Institute of Standards and Technology (NIST) [DOC]

Boston, Massachusetts 02115-5005 United States

Single Zip Code

Measurement Science and Engineering (MSE) Research Grant Programs (2021-NIST-MSE-01)

Amendment Since initial award the End Date has been extended from 07/31/25 to 07/31/26.