70NANB22H016
Cooperative Agreement
Overview
Grant Description
Title: Domestic Supply Chain for Vaccine Manufacturing
Purpose:
The purpose of this grant is to develop and demonstrate pilot-scale manufacturing of vaccine adjuvants from sustainable domestic sources, through microbial fermentation processes or extraction from easily grown domestic plants.
Activities to be Performed:
The project team will build pilot- and intermediate-scale production of sustainable squalene and develop microbial synthesis of plant saponins for use as vaccine adjuvants.
Expected Outcomes:
Successful completion of these projects will resolve specific supply chain issues for critical vaccine components. The research will identify sustainable domestic sources of vaccine adjuvants that provide a long-term solution to replacing current adjuvants that are currently produced from ecologically unfriendly and geopolitically unstable foreign sourcing.
Intended Beneficiaries:
Vaccine manufacturers will benefit by having more robust adjuvant supply chains for vaccine production. The emerging U.S. bioindustrial sector will benefit by developing a high-quality and domestic alternative for raw material valued by vaccine manufacturers and through gaining greater insight into real-world industrial applications and markets. The U.S. public will benefit by having more secure domestic supply chains for vaccines.
Subrecipient Activities:
The recipient plans to subaward funds to scale up fermentation and downstream purification unit operations, harvest purified saponin from domestic Quillaja saponins trees, and produce adjuvant material for this research project.
Purpose:
The purpose of this grant is to develop and demonstrate pilot-scale manufacturing of vaccine adjuvants from sustainable domestic sources, through microbial fermentation processes or extraction from easily grown domestic plants.
Activities to be Performed:
The project team will build pilot- and intermediate-scale production of sustainable squalene and develop microbial synthesis of plant saponins for use as vaccine adjuvants.
Expected Outcomes:
Successful completion of these projects will resolve specific supply chain issues for critical vaccine components. The research will identify sustainable domestic sources of vaccine adjuvants that provide a long-term solution to replacing current adjuvants that are currently produced from ecologically unfriendly and geopolitically unstable foreign sourcing.
Intended Beneficiaries:
Vaccine manufacturers will benefit by having more robust adjuvant supply chains for vaccine production. The emerging U.S. bioindustrial sector will benefit by developing a high-quality and domestic alternative for raw material valued by vaccine manufacturers and through gaining greater insight into real-world industrial applications and markets. The U.S. public will benefit by having more secure domestic supply chains for vaccines.
Subrecipient Activities:
The recipient plans to subaward funds to scale up fermentation and downstream purification unit operations, harvest purified saponin from domestic Quillaja saponins trees, and produce adjuvant material for this research project.
Funding Goals
TO FUND HIGH-IMPACT PROJECTS DESIGNED TO FUND AWARDS FOR RESEARCH, DEVELOPMENT, AND TESTBEDS TO PREVENT, PREPARE FOR, AND RESPOND TO CORONAVIRUS.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Emeryville,
California
94608-1020
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
COVID-19 $4,729,691 (100%) percent of this Cooperative Agreement was funded by COVID-19 emergency acts including the American Rescue Plan Act of 2021.
Amendment Since initial award the End Date has been extended from 02/29/24 to 06/30/25.
Amendment Since initial award the End Date has been extended from 02/29/24 to 06/30/25.
Bioindustrial Manufacturing And Design Ecosystem was awarded
Developing Sustainable Domestic Supply Chain Vaccine Adjuvants
Cooperative Agreement 70NANB22H016
worth $4,729,691
from the National Institute of Standards and Technology in March 2022 with work to be completed primarily in Emeryville California United States.
The grant
has a duration of 3 years 3 months and
was awarded through assistance program 11.619 Arrangements for Interdisciplinary Research Infrastructure.
$212,892 (4.0%) of this Cooperative Agreement was funded by non-federal sources.
The Cooperative Agreement was awarded through grant opportunity NIST Rapid Assistance for Coronavirus Economic Response (RACER).
Status
(Complete)
Last Modified 8/21/25
Period of Performance
3/1/22
Start Date
6/30/25
End Date
Funding Split
$4.7M
Federal Obligation
$212.9K
Non-Federal Obligation
$4.9M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for 70NANB22H016
Transaction History
Modifications to 70NANB22H016
Additional Detail
Award ID FAIN
70NANB22H016
SAI Number
70NANB22H016_3
Award ID URI
EXE
Awardee Classifications
Other
Awarding Office
1333ND DEPT OF COMMERCE NIST
Funding Office
1333ND DEPT OF COMMERCE NIST
Awardee UEI
FL9NQMBGDQK1
Awardee CAGE
8P6N7
Performance District
CA-12
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Industrial Technology Services, National Institute of Standards and Technology, Commerce (013-0525) | Other advancement of commerce | Grants, subsidies, and contributions (41.0) | $4,729,691 | 100% |
Modified: 8/21/25