2532118
Cooperative Agreement
Overview
Grant Description
NSF RuralStamina Biomanufacturing Engine in Iowa and Nebraska - The NSF RuralStamina Biomanufacturing Engine in Iowa and Nebraska will advance the nation’s capacity for innovation in advanced biomanufacturing by transforming agricultural feedstocks into a wide range of value-added bioproducts, spanning industrial materials, food and feed ingredients, fuels, and vaccines.
At the scale, speed, and RELIABILITY needed to strengthen national security and rural economic prosperity.
RuralStamina builds an unprecedented domestic biomanufacturing base of great significance rooted in American agriculture, directly aligned with the U.S. government’s biomanufacturing strategy and its call for a resilient domestic supply chain for products critical to defense, health, and industry.
The NSF RuralStamina Engine positions the Iowa and Nebraska region of service for national leadership in advanced manufacturing of bio-based products, catalyzes prosperity in agricultural and rural communities across the region, and strengthens U.S. competitiveness in this strategically important sector while reducing dependence on foreign sources.
The strategy is direct: build the biomanufacturing economy where the biomass is grown.
The technical goals for RuralStamina Engine R&D investments include bridging critical R&D gaps to move biomanufacturing innovations from the lab to pilot scale through (I) developing enabling technologies such as new microorganisms for biomanufacturing of new value-added products; (II) predictable and reliable scaling up of biomanufacturing processes for commercialization, and (III) designing and deploying sensors and AI tools for biomanufacturing process optimization.
The vision of RuralStamina is to lead a domestic revolution in biomanufacturing in America’s agricultural heartland where products can be manufactured close to where raw materials are most abundant.
The NSF RuralStamina Engine brings together a powerful coalition of more than 80 public and private partners and stakeholders and aligns with regional assets, investments, and national priorities.
It has identified critical R&D topic areas that must be advanced to drive innovations for advanced biomanufacturing.
The engine will support these R&D focus areas, improve translation of innovations, and expand workforce development activities to cultivate a thriving regional innovation ecosystem of tech companies, researchers, innovators, investors, farmers, and community and industry leaders that will transform Iowa and Nebraska into a national hub for biomanufacturing innovation.
The workforce development investments of RuralStamina are designed to meet the needs of the population in rural Iowa and Nebraska, wherever they are in their career trajectories.
RuralStamina will expand the biomanufacturing workforce at all levels from process and product engineers to skilled operators, technicians, and researchers to achieve biomanufacturing dominance.
The engine partners maintain meaningful connections with youth, workforce development, and business leaders across all 192 counties in Iowa and Nebraska.
RuralStamina will grow a robust domestic supply chain that will unleash U.S. competitiveness and strengthen rural America.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
At the scale, speed, and RELIABILITY needed to strengthen national security and rural economic prosperity.
RuralStamina builds an unprecedented domestic biomanufacturing base of great significance rooted in American agriculture, directly aligned with the U.S. government’s biomanufacturing strategy and its call for a resilient domestic supply chain for products critical to defense, health, and industry.
The NSF RuralStamina Engine positions the Iowa and Nebraska region of service for national leadership in advanced manufacturing of bio-based products, catalyzes prosperity in agricultural and rural communities across the region, and strengthens U.S. competitiveness in this strategically important sector while reducing dependence on foreign sources.
The strategy is direct: build the biomanufacturing economy where the biomass is grown.
The technical goals for RuralStamina Engine R&D investments include bridging critical R&D gaps to move biomanufacturing innovations from the lab to pilot scale through (I) developing enabling technologies such as new microorganisms for biomanufacturing of new value-added products; (II) predictable and reliable scaling up of biomanufacturing processes for commercialization, and (III) designing and deploying sensors and AI tools for biomanufacturing process optimization.
The vision of RuralStamina is to lead a domestic revolution in biomanufacturing in America’s agricultural heartland where products can be manufactured close to where raw materials are most abundant.
The NSF RuralStamina Engine brings together a powerful coalition of more than 80 public and private partners and stakeholders and aligns with regional assets, investments, and national priorities.
It has identified critical R&D topic areas that must be advanced to drive innovations for advanced biomanufacturing.
The engine will support these R&D focus areas, improve translation of innovations, and expand workforce development activities to cultivate a thriving regional innovation ecosystem of tech companies, researchers, innovators, investors, farmers, and community and industry leaders that will transform Iowa and Nebraska into a national hub for biomanufacturing innovation.
The workforce development investments of RuralStamina are designed to meet the needs of the population in rural Iowa and Nebraska, wherever they are in their career trajectories.
RuralStamina will expand the biomanufacturing workforce at all levels from process and product engineers to skilled operators, technicians, and researchers to achieve biomanufacturing dominance.
The engine partners maintain meaningful connections with youth, workforce development, and business leaders across all 192 counties in Iowa and Nebraska.
RuralStamina will grow a robust domestic supply chain that will unleash U.S. competitiveness and strengthen rural America.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF REGIONAL INNOVATION ENGINES", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF24565
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Ames,
Iowa
50011-2103
United States
Geographic Scope
Single Zip Code
Related Opportunity
Iowa State University Of Science And Technology was awarded
Revolutionizing Biomanufacturing in Iowa Nebraska National Prosperity
Cooperative Agreement 2532118
worth $7,499,902
from National Science Foundation in August 2026 with work to be completed primarily in Ames Iowa United States.
The grant
has a duration of 10 years and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Cooperative Agreement was awarded through grant opportunity NSF Regional Innovation Engines.
Status
(Ongoing)
Last Modified 7/17/26
Period of Performance
8/1/26
Start Date
7/31/36
End Date
Funding Split
$7.5M
Federal Obligation
$0.0
Non-Federal Obligation
$7.5M
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2532118
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
491502 INNOVATION AND TECHNOLOGY ECOSYSTEMS
Funding Office
491502 INNOVATION AND TECHNOLOGY ECOSYSTEMS
Awardee UEI
DQDBM7FGJPC5
Awardee CAGE
5J949
Performance District
IA-04
Senators
Charles Grassley
Joni Ernst
Joni Ernst
Modified: 7/17/26