2514598
Project Grant
Overview
Grant Description
Crest Phase I: Center for Circadian Rhythmicity and Sleep Homeostasis
With support from the Centers for Research Excellence in Science and Technology (CREST), this project aims to study sleep and internal circadian clocks that regulate sleep-wake cycles.
These investigations are significant because lack of sleep has been associated with individuals whose occupations require shift-work.
How circadian disruptions affect sleep is unknown.
This project will identify how circadian disruptions affect the body.
The goal of the project is to establish a world-class research center for circadian system biology.
The research questions will focus on understanding how circadian rhythms adapt/resynchronize in response to frequently disrupted and ever-changing stimuli.
The center aims to: identify the neuronal network mechanisms by which light-dark signals are integrated by the circadian clock in the brain; probe the molecular mechanisms for the synchronization of circadian clocks outside of the brain; and determine the neurocircuitry underlying sleep.
Research methods will include spatial transcriptomics, proteomics, computational neurobiology, and in vivo brain imaging.
The project's scope will engage collaborators to leverage additional cutting-edge technologies.
The expected results are the identification of cellular and molecular mechanisms responsible for circadian disruptions.
Results will be disseminated at meetings and in publications for the scientific and lay communities.
Broader impacts include understanding and mitigating the adverse impact of circadian disruptions and training opportunities for students and faculty.
The Center of Research Excellence in Science and Technology (CREST) program provides support to enhance the research capability capabilities of institutions through the establishment of centers that effectively integrate education and research.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
With support from the Centers for Research Excellence in Science and Technology (CREST), this project aims to study sleep and internal circadian clocks that regulate sleep-wake cycles.
These investigations are significant because lack of sleep has been associated with individuals whose occupations require shift-work.
How circadian disruptions affect sleep is unknown.
This project will identify how circadian disruptions affect the body.
The goal of the project is to establish a world-class research center for circadian system biology.
The research questions will focus on understanding how circadian rhythms adapt/resynchronize in response to frequently disrupted and ever-changing stimuli.
The center aims to: identify the neuronal network mechanisms by which light-dark signals are integrated by the circadian clock in the brain; probe the molecular mechanisms for the synchronization of circadian clocks outside of the brain; and determine the neurocircuitry underlying sleep.
Research methods will include spatial transcriptomics, proteomics, computational neurobiology, and in vivo brain imaging.
The project's scope will engage collaborators to leverage additional cutting-edge technologies.
The expected results are the identification of cellular and molecular mechanisms responsible for circadian disruptions.
Results will be disseminated at meetings and in publications for the scientific and lay communities.
Broader impacts include understanding and mitigating the adverse impact of circadian disruptions and training opportunities for students and faculty.
The Center of Research Excellence in Science and Technology (CREST) program provides support to enhance the research capability capabilities of institutions through the establishment of centers that effectively integrate education and research.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "CENTERS OF RESEARCH EXCELLENCE IN SCIENCE AND TECHNOLOGY", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF23595
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Atlanta,
Georgia
30310-1458
United States
Geographic Scope
Single Zip Code
Related Opportunity
The Morehouse School Of Medicine was awarded
Circadian Rhythms & Sleep Study: Establishing a World-Class Research Center
Project Grant 2514598
worth $7,394,696
from the Division of Human Resource Development in September 2025 with work to be completed primarily in Atlanta Georgia United States.
The grant
has a duration of 5 years and
was awarded through assistance program 47.076 Education and Human Resources.
The Project Grant was awarded through grant opportunity Centers of Research Excellence in Science and Technology.
Status
(Ongoing)
Last Modified 8/21/25
Period of Performance
9/1/25
Start Date
8/31/30
End Date
Funding Split
$7.4M
Federal Obligation
$0.0
Non-Federal Obligation
$7.4M
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2514598
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
491106 DIVISION OF EQUITY FOR EXCELLENCE IN STEM
Funding Office
491106 DIVISION OF EQUITY FOR EXCELLENCE IN STEM
Awardee UEI
X5S7PNXMJMC7
Awardee CAGE
0CWL6
Performance District
GA-05
Senators
Jon Ossoff
Raphael Warnock
Raphael Warnock
Modified: 8/21/25