2451630
Project Grant
Overview
Grant Description
SBIR Phase I: Scaling up tunable high-frequency microwave heating for pharmaceutical and biologics manufacturing.
This Small Business Innovation Research (SBIR) Phase I project will result in fundamental knowledge needed to solve the scale-up problem for fast, uniform, volumetric heating during manufacturing of freeze-dried medicines, diagnostics, preservative-free foods, and other high-value sensitive materials.
The findings will facilitate a significant improvement in manufacturing capacity for most freeze-dried goods and ultimately provide a pathway towards addressing recurring shortages and securing long-term availability.
This SBIR research will produce data critical for process understanding as well as new quality control methodologies necessary for regulatory acceptance of microwave drying.
The technology will be initially marketed to research and development units or organizations having a clear and viable downstream pathway towards manufacturing.
The key competitive advantages offered by the technology are its ability to be noninvasively retrofitted to both new and legacy freeze-drying systems and its capability of producing uniform high-frequency electromagnetic fields specifically targeted towards frozen materials.
This Small Business Innovation Research (SBIR) Phase I project aims to improve manufacturing performance of high-value freeze-dried materials having limited shelf life using high-frequency microwave heating.
The overall goal of the project is to gain the fundamental knowledge required to effectively scale the technology from laboratory to large-volume manufacturing freeze-drying systems.
Key research objectives to be addressed include developing new experimental methods for estimating the effective dielectric properties of frozen aqueous solutions and primary packaging, identifying appropriate physics-based models and parameters for system modeling, and implementing model-based closed-loop control strategies to drive the freeze-drying process at optimal rates.
To accomplish these tasks, multiple microwave sources will be fabricated and installed on a modified laboratory freeze-dryer together with a suite of temperature sensing technologies.
Experimental measurements will provide the data necessary to develop the coupled unsteady electromagnetic and heat and mass transfer simulations for identifying the scale-up characteristics, microwave source interaction, and volumetric heating performance.
Free radical production in the vacuum environment and material compatibility with the electric fields over the system bandwidth will also be assessed either explicitly using appropriate probes or implicitly via bioindicators.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
This Small Business Innovation Research (SBIR) Phase I project will result in fundamental knowledge needed to solve the scale-up problem for fast, uniform, volumetric heating during manufacturing of freeze-dried medicines, diagnostics, preservative-free foods, and other high-value sensitive materials.
The findings will facilitate a significant improvement in manufacturing capacity for most freeze-dried goods and ultimately provide a pathway towards addressing recurring shortages and securing long-term availability.
This SBIR research will produce data critical for process understanding as well as new quality control methodologies necessary for regulatory acceptance of microwave drying.
The technology will be initially marketed to research and development units or organizations having a clear and viable downstream pathway towards manufacturing.
The key competitive advantages offered by the technology are its ability to be noninvasively retrofitted to both new and legacy freeze-drying systems and its capability of producing uniform high-frequency electromagnetic fields specifically targeted towards frozen materials.
This Small Business Innovation Research (SBIR) Phase I project aims to improve manufacturing performance of high-value freeze-dried materials having limited shelf life using high-frequency microwave heating.
The overall goal of the project is to gain the fundamental knowledge required to effectively scale the technology from laboratory to large-volume manufacturing freeze-drying systems.
Key research objectives to be addressed include developing new experimental methods for estimating the effective dielectric properties of frozen aqueous solutions and primary packaging, identifying appropriate physics-based models and parameters for system modeling, and implementing model-based closed-loop control strategies to drive the freeze-drying process at optimal rates.
To accomplish these tasks, multiple microwave sources will be fabricated and installed on a modified laboratory freeze-dryer together with a suite of temperature sensing technologies.
Experimental measurements will provide the data necessary to develop the coupled unsteady electromagnetic and heat and mass transfer simulations for identifying the scale-up characteristics, microwave source interaction, and volumetric heating performance.
Free radical production in the vacuum environment and material compatibility with the electric fields over the system bandwidth will also be assessed either explicitly using appropriate probes or implicitly via bioindicators.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH / SMALL BUSINESS TECHNOLOGY TRANSFER PHASE I PROGRAMS", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF24579
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
West Lafayette,
Indiana
47906-4363
United States
Geographic Scope
Single Zip Code
Lyowave was awarded
Project Grant 2451630
worth $304,436
from National Science Foundation in March 2025 with work to be completed primarily in West Lafayette Indiana United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Project Grant was awarded through grant opportunity NSF Small Business Innovation Research / Small Business Technology Transfer Phase I Programs.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: Scaling Up Tunable High-Frequency Microwave Heating for Pharmaceutical and Biologics Manufacturing
Abstract
This Small Business Innovation Research (SBIR) Phase I project will result in fundamental knowledge needed to solve the scale-up problem for fast, uniform, volumetric heating during manufacturing of freeze-dried medicines, diagnostics, preservative-free foods, and other high-value sensitive materials. The findings will facilitate a significant improvement in manufacturing capacity for most freeze-dried goods and ultimately provide a pathway towards addressing recurring shortages and securing long-term availability. This SBIR research will produce data critical for process understanding as well as new quality control methodologies necessary for regulatory acceptance of microwave drying. The technology will be initially marketed to research and development units or organizations having a clear and viable downstream pathway towards manufacturing. The key competitive advantages offered by the technology are its ability to be noninvasively retrofitted to both new and legacy freeze-drying systems and its capability of producing uniform high-frequency electromagnetic fields specifically targeted towards frozen materials. This Small Business Innovation Research (SBIR) Phase I project aims to improve manufacturing performance of high-value freeze-dried materials having limited shelf life using high-frequency microwave heating. The overall goal of the project is to gain the fundamental knowledge required to effectively scale the technology from laboratory to large-volume manufacturing freeze-drying systems. Key research objectives to be addressed include developing new experimental methods for estimating the effective dielectric properties of frozen aqueous solutions and primary packaging, identifying appropriate physics-based models and parameters for system modeling, and implementing model-based closed-loop control strategies to drive the freeze-drying process at optimal rates. To accomplish these tasks, multiple microwave sources will be fabricated and installed on a mo
Topic Code
M
Solicitation Number
NSF 24-579
Status
(Ongoing)
Last Modified 3/5/25
Period of Performance
3/1/25
Start Date
2/28/26
End Date
Funding Split
$304.4K
Federal Obligation
$0.0
Non-Federal Obligation
$304.4K
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2451630
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
Z8RNCMMDGZP3
Awardee CAGE
None
Performance District
IN-04
Senators
Todd Young
Mike Braun
Mike Braun
Modified: 3/5/25