2451418
Project Grant
Overview
Grant Description
SBIR Phase I: User-centric super resolution imaging system dissecting molecular composition and ultrastructure in cells and tissues.
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project lies in its ability to revolutionize biomedical research by enabling advanced fluorescence imaging of biological tissues at unprecedented depth and resolution.
The technology's ability to provide precise three-dimensional imaging of molecular structures in thick tissue samples offers significant advancements in drug discovery, disease diagnostics, basic biological research, and biological education.
This innovation has the potential to fill a major gap in the high-end microscopy market, providing researchers with tools that surpass the limitations of current imaging systems, fostering breakthroughs in life sciences.
This Small Business Innovation Research (SBIR) Phase I project aims to develop a compact, multi-color super-resolution imaging system capable of imaging thick biological tissues with nanoscale precision.
The project addresses the limitations of existing imaging technologies, which are restricted in depth and resolution, by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering.
The research objectives include optimizing the system for imaging up to 250 micrometers in depth with a resolution of 10-20 nanometers and demonstrating its capability to visualize multiple molecular targets simultaneously.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project lies in its ability to revolutionize biomedical research by enabling advanced fluorescence imaging of biological tissues at unprecedented depth and resolution.
The technology's ability to provide precise three-dimensional imaging of molecular structures in thick tissue samples offers significant advancements in drug discovery, disease diagnostics, basic biological research, and biological education.
This innovation has the potential to fill a major gap in the high-end microscopy market, providing researchers with tools that surpass the limitations of current imaging systems, fostering breakthroughs in life sciences.
This Small Business Innovation Research (SBIR) Phase I project aims to develop a compact, multi-color super-resolution imaging system capable of imaging thick biological tissues with nanoscale precision.
The project addresses the limitations of existing imaging technologies, which are restricted in depth and resolution, by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering.
The research objectives include optimizing the system for imaging up to 250 micrometers in depth with a resolution of 10-20 nanometers and demonstrating its capability to visualize multiple molecular targets simultaneously.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH / SMALL BUSINESS TECHNOLOGY TRANSFER PHASE I PROGRAMS", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF24579
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
West Lafayette,
Indiana
47906-1132
United States
Geographic Scope
Single Zip Code
Nanores was awarded
Project Grant 2451418
worth $305,000
from National Science Foundation in March 2025 with work to be completed primarily in West Lafayette Indiana United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Project Grant was awarded through grant opportunity NSF Small Business Innovation Research / Small Business Technology Transfer Phase I Programs.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: User-Centric Super Resolution Imaging System Dissecting Molecular Composition and Ultrastructure in Cells and Tissues
Abstract
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project lies in its ability to revolutionize biomedical research by enabling advanced fluorescence imaging of biological tissues at unprecedented depth and resolution. The technology's ability to provide precise three-dimensional imaging of molecular structures in thick tissue samples offers significant advancements in drug discovery, disease diagnostics, basic biological research, and biological education. This innovation has the potential to fill a major gap in the high-end microscopy market, providing researchers with tools that surpass the limitations of current imaging systems, fostering breakthroughs in life sciences. This Small Business Innovation Research (SBIR) Phase I project aims to develop a compact, multi-color super-resolution imaging system capable of imaging thick biological tissues with nanoscale precision. The project addresses the limitations of existing imaging technologies, which are restricted in depth and resolution, by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering. The research objectives include optimizing the system for imaging up to 250 micrometers in depth with a resolution of 10–20 nanometers and demonstrating its capability to visualize multiple molecular targets simultaneously. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BM
Solicitation Number
NSF 24-579
Status
(Ongoing)
Last Modified 3/5/25
Period of Performance
3/1/25
Start Date
2/28/26
End Date
Funding Split
$305.0K
Federal Obligation
$0.0
Non-Federal Obligation
$305.0K
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2451418
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
N35GQ6U1RC67
Awardee CAGE
9RBD8
Performance District
IN-04
Senators
Todd Young
Mike Braun
Mike Braun
Modified: 3/5/25