2432611
Project Grant
Overview
Grant Description
SBIR Phase I: A nano-optical imaging microendoscope for in vivo imaging - The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will enable researchers to visualize the dynamics of the biological events in live animals.
The product, the miniaturized optical imaging micro-endoscope, will change researchers' current paradigm of only visualizing and exploring the superficial layers of tissue at a subcellular level.
Visualizing the deeper layers of tissue in >1 mm depth at the subcellular level using the miniaturized optical imaging micro-endoscope will enable a range of discoveries in different areas of biomedical research.
In the long term, the developed product can be utilized by physicians to improve the current standards of care in various medical applications.
This Small Business Innovation Research (SBIR) Phase I project is developing a nanophotonic imaging microendoscope for in vivo imaging with minimal damage.
Current optical microscopy imaging cannot be used for imaging beyond 1 mm depth.
The current microendoscopes have a diameter larger than 0.5-1 mm, so they cause severe damage to the tissue when inserted into the tissue.
The current microendoscopes cannot provide images in >1 mm depth since the damage to the tissue changes the whole tissue structure.
Miniaturized microendoscopic tools with subcellular resolution are vital for deep tissue imaging (>1 mm).
The product of this SBIR project will be 100 µm diameter, a hair-size micro-endoscope allowing researchers and scientists to conduct their studies at >3 mm depth in a live animal.
The state of the art of optical design and nanofabrication techniques will be utilized to make the miniaturized microendoscope.
This project will lead to derisking the risks associated with the miniaturization of the optical microendoscope and enabling its usage for in vivo imaging.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
The product, the miniaturized optical imaging micro-endoscope, will change researchers' current paradigm of only visualizing and exploring the superficial layers of tissue at a subcellular level.
Visualizing the deeper layers of tissue in >1 mm depth at the subcellular level using the miniaturized optical imaging micro-endoscope will enable a range of discoveries in different areas of biomedical research.
In the long term, the developed product can be utilized by physicians to improve the current standards of care in various medical applications.
This Small Business Innovation Research (SBIR) Phase I project is developing a nanophotonic imaging microendoscope for in vivo imaging with minimal damage.
Current optical microscopy imaging cannot be used for imaging beyond 1 mm depth.
The current microendoscopes have a diameter larger than 0.5-1 mm, so they cause severe damage to the tissue when inserted into the tissue.
The current microendoscopes cannot provide images in >1 mm depth since the damage to the tissue changes the whole tissue structure.
Miniaturized microendoscopic tools with subcellular resolution are vital for deep tissue imaging (>1 mm).
The product of this SBIR project will be 100 µm diameter, a hair-size micro-endoscope allowing researchers and scientists to conduct their studies at >3 mm depth in a live animal.
The state of the art of optical design and nanofabrication techniques will be utilized to make the miniaturized microendoscope.
This project will lead to derisking the risks associated with the miniaturization of the optical microendoscope and enabling its usage for in vivo imaging.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH (SBIR)/ SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS PHASE I", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF23515
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Rockville,
Maryland
20850-0392
United States
Geographic Scope
Single Zip Code
Lensguide Imaging Technology was awarded
Project Grant 2432611
worth $275,000
from National Science Foundation in September 2024 with work to be completed primarily in Rockville Maryland United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Project Grant was awarded through grant opportunity NSF Small Business Innovation Research / Small Business Technology Transfer Phase I Programs.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: A nano-optical imaging microendoscope for in vivo Imaging
Abstract
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will enable researchers to visualize the dynamics of the biological events in live animals. The product, the miniaturized optical imaging micro-endoscope, will change researchers’ current paradigm of only visualizing and exploring the superficial layers of tissue at a subcellular level. Visualizing the deeper layers of tissue in >1 mm depth at the subcellular level using the miniaturized optical imaging micro-endoscope will enable a range of discoveries in different areas of biomedical research. In the long term, the developed product can be utilized by physicians to improve the current standards of care in various medical applications.
This Small Business Innovation Research (SBIR) Phase I project is developing a nanophotonic imaging microendoscope for in vivo imaging with minimal damage. Current optical microscopy imaging cannot be used for imaging beyond 1 mm depth. The current microendoscopes have a diameter larger than 0.5-1 mm, so they cause severe damage to the tissue when inserted into the tissue. The current microendoscopes cannot provide images in >1 mm depth since the damage to the tissue changes the whole tissue structure. Miniaturized microendoscopic tools with subcellular resolution are vital for deep tissue imaging (>1 mm). The product of this SBIR project will be 100 µm diameter, a hair-size micro-endoscope allowing researchers and scientists to conduct their studies at >3 mm depth in a live animal. The state of the art of optical design and nanofabrication techniques will be utilized to make the miniaturized microendoscope. This project will lead to derisking the risks associated with the miniaturization of the optical microendoscope and enabling its usage for in vivo imaging.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BM
Solicitation Number
NSF 23-515
Status
(Complete)
Last Modified 9/17/24
Period of Performance
9/1/24
Start Date
8/31/25
End Date
Funding Split
$275.0K
Federal Obligation
$0.0
Non-Federal Obligation
$275.0K
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2432611
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
VGLLXNMDNHQ5
Awardee CAGE
872N0
Performance District
MD-08
Senators
Benjamin Cardin
Chris Van Hollen
Chris Van Hollen
Modified: 9/17/24