2423477
Project Grant
Overview
Grant Description
SBIR Phase I: Bioengineered next-generation tympanostomy tubes to improve patient outcomes.
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the advancement of implantable medical devices through innovative use of natural biopolymers, specifically silk and chitosan.
Through the development of a novel manufacturing approach optimized for biopolymers, this project addresses significant limitations in traditional manufacturing methods and unlocks the potential of biopolymers for complex medical applications.
The anticipated commercial impact includes reducing healthcare costs and improving patient outcomes, particularly for the millions of children requiring tympanostomy tubes annually.
This project aims to eliminate the need for surgical removal of tympanostomy tubes by creating degradable, biocompatible, and antimicrobial alternatives, ultimately enhancing the quality of pediatric care and expanding market opportunities for advanced biomaterials in medical devices.
This Small Business Innovation Research (SBIR) Phase I project focuses on a groundbreaking method to manufacture biopolymer-based implants using 3D printed molds, centrifugation, and polymerization.
Unlike traditional manufacturing techniques, this approach ensures high fidelity to intricate geometries, minimizes waste, and allows for rapid prototyping.
The project aims to develop degrade on-demand tympanostomy tubes from natural biopolymers with inherent antimicrobial properties.
The research objectives include optimizing the manufacturing process, testing mechanical properties, and ensuring consistent quality.
Anticipated technical results include demonstrating scalable production of complex 3D structures with superior mechanical integrity and biocompatibility, paving the way for broader application of natural biopolymers in various medical fields.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the advancement of implantable medical devices through innovative use of natural biopolymers, specifically silk and chitosan.
Through the development of a novel manufacturing approach optimized for biopolymers, this project addresses significant limitations in traditional manufacturing methods and unlocks the potential of biopolymers for complex medical applications.
The anticipated commercial impact includes reducing healthcare costs and improving patient outcomes, particularly for the millions of children requiring tympanostomy tubes annually.
This project aims to eliminate the need for surgical removal of tympanostomy tubes by creating degradable, biocompatible, and antimicrobial alternatives, ultimately enhancing the quality of pediatric care and expanding market opportunities for advanced biomaterials in medical devices.
This Small Business Innovation Research (SBIR) Phase I project focuses on a groundbreaking method to manufacture biopolymer-based implants using 3D printed molds, centrifugation, and polymerization.
Unlike traditional manufacturing techniques, this approach ensures high fidelity to intricate geometries, minimizes waste, and allows for rapid prototyping.
The project aims to develop degrade on-demand tympanostomy tubes from natural biopolymers with inherent antimicrobial properties.
The research objectives include optimizing the manufacturing process, testing mechanical properties, and ensuring consistent quality.
Anticipated technical results include demonstrating scalable production of complex 3D structures with superior mechanical integrity and biocompatibility, paving the way for broader application of natural biopolymers in various medical fields.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Subawards are not planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH (SBIR)/ SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS PHASE I", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF23515
Grant Program (CFDA)
Awarding Agency
Place of Performance
Somerville,
Massachusetts
02144-1219
United States
Geographic Scope
Single Zip Code
Materialize Bio was awarded
Project Grant 2423477
worth $274,999
from in September 2024 with work to be completed primarily in Somerville Massachusetts United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Project Grant was awarded through grant opportunity NSF Small Business Innovation Research / Small Business Technology Transfer Phase I Programs.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: Bioengineered Next-Generation Tympanostomy Tubes to Improve Patient Outcomes
Abstract
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the advancement of implantable medical devices through innovative use of natural biopolymers, specifically silk and chitosan. Through the development of a novel manufacturing approach optimized for biopolymers, this project addresses significant limitations in traditional manufacturing methods and unlocks the potential of biopolymers for complex medical applications. The anticipated commercial impact includes reducing healthcare costs and improving patient outcomes, particularly for the millions of children requiring tympanostomy tubes annually. This project aims to eliminate the need for surgical removal of tympanostomy tubes by creating degradable, biocompatible, and antimicrobial alternatives, ultimately enhancing the quality of pediatric care and expanding market opportunities for advanced biomaterials in medical devices.
This Small Business Innovation Research (SBIR) Phase I project focuses on a groundbreaking method to manufacture biopolymer-based implants using 3D printed molds, centrifugation, and polymerization. Unlike traditional manufacturing techniques, this approach ensures high fidelity to intricate geometries, minimizes waste, and allows for rapid prototyping. The project aims to develop degrade on-demand tympanostomy tubes from natural biopolymers with inherent antimicrobial properties. The research objectives include optimizing the manufacturing process, testing mechanical properties, and ensuring consistent quality. Anticipated technical results include demonstrating scalable production of complex 3D structures with superior mechanical integrity and biocompatibility, paving the way for broader application of natural biopolymers in various medical fields.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BM
Solicitation Number
NSF 23-515
Status
(Complete)
Last Modified 7/17/25
Period of Performance
9/1/24
Start Date
8/31/25
End Date
Funding Split
$275.0K
Federal Obligation
$0.0
Non-Federal Obligation
$275.0K
Total Obligated
Activity Timeline
Transaction History
Modifications to 2423477
Additional Detail
Award ID FAIN
2423477
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
C3ZSVA4QXSQ4
Awardee CAGE
0M9Q1
Performance District
MA-07
Senators
Edward Markey
Elizabeth Warren
Elizabeth Warren
Modified: 7/17/25