2403910
Project Grant
Overview
Grant Description
Sttr phase I: high-resolution, spatially selective intraspinal stimulator to restore sensation in spinal cord injury patients. -The broader impact/commercial potential of this small business technology transfer (STTR) phase I project is a novel custom-made micro-probe electrode system for restoring organ function in nervous paralysis and paralysis-related conditions such as neurogenic bladder or fecal incontinence. The electrode system aims to provide real-time, bi-directional, closed-loop spinal cord machine interface to restore both sensation and volitional motor control in spinal cord injury (SCI) patients.
The system aims to provide restorative function for the 5.4M US paralysis victims, while providing smaller, more accurate, higher capacity implantable electrode platform for the $7.6 B neurorehabilitation and neurostimulation market. This small business technology transfer (STTR) phase I project aims to demonstrate the preclinical feasibility of a novel spinal cord neural interface as an effective scalable platform for rehabilitating paralysis-related conditions including neurogenic bladder and mobility. This project will develop a new type of neural interface that delivers selective stimulation to specific targeted regions of the patient?s spinal cord in order to evoke a target sensation.
For example, bladder fullness will trigger the proposed intraspinal stimulator to deliver safe current pulses to the patient?s spinal cord to reenable the sensation of bladder fullness. The proposed probe will also sense the patient?s intention to urinate and relay the signal to a bladder stimulator to reenable patient?s control over their micturition. Nanopatterned stimulating electrodes will be fabricated and coupled with custom-designed complementary metal oxide semiconductor (CMOS) chips to deliver safe and spatially selective current pulses. The system aims to bypass the spinal cord injury to restore communication between the subject?s body and brain.
The system will be validated in rodent nervous models and characterized for future human use. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria. - Subawards are planned for this award.
The system aims to provide restorative function for the 5.4M US paralysis victims, while providing smaller, more accurate, higher capacity implantable electrode platform for the $7.6 B neurorehabilitation and neurostimulation market. This small business technology transfer (STTR) phase I project aims to demonstrate the preclinical feasibility of a novel spinal cord neural interface as an effective scalable platform for rehabilitating paralysis-related conditions including neurogenic bladder and mobility. This project will develop a new type of neural interface that delivers selective stimulation to specific targeted regions of the patient?s spinal cord in order to evoke a target sensation.
For example, bladder fullness will trigger the proposed intraspinal stimulator to deliver safe current pulses to the patient?s spinal cord to reenable the sensation of bladder fullness. The proposed probe will also sense the patient?s intention to urinate and relay the signal to a bladder stimulator to reenable patient?s control over their micturition. Nanopatterned stimulating electrodes will be fabricated and coupled with custom-designed complementary metal oxide semiconductor (CMOS) chips to deliver safe and spatially selective current pulses. The system aims to bypass the spinal cord injury to restore communication between the subject?s body and brain.
The system will be validated in rodent nervous models and characterized for future human use. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria. - Subawards are planned for this award.
Awardee
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH (SBIR)/ SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS PHASE I", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF23515
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Los Angeles,
California
90068-1153
United States
Geographic Scope
Single Zip Code
Ecate was awarded
Project Grant 2403910
worth $274,976
from National Science Foundation in June 2024 with work to be completed primarily in Los Angeles California United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
The Project Grant was awarded through grant opportunity NSF Small Business Innovation Research / Small Business Technology Transfer Phase I Programs.
SBIR Details
Research Type
STTR Phase I
Title
STTR Phase I: High-resolution, spatially selective intraspinal stimulator to restore sensation in spinal cord injury patients.
Abstract
The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel custom-made micro-probe electrode system for restoring organ function in nervous paralysis and paralysis-related conditions such as neurogenic bladder or fecal incontinence. The electrode system aims to provide real-time, bi-directional, closed-loop spinal cord machine interface to restore both sensation and volitional motor control in spinal cord injury (SCI) patients. The system aims to provide restorative function for the 5.4M US paralysis victims, while providing smaller, more accurate, higher capacity implantable electrode platform for the $7.6 B neurorehabilitation and neurostimulation market.
This Small Business Technology Transfer (STTR) Phase I project aims to demonstrate the preclinical feasibility of a novel spinal cord neural interface as an effective scalable platform for rehabilitating paralysis-related conditions including neurogenic bladder and mobility. This project will develop a new type of neural interface that delivers selective stimulation to specific targeted regions of the patient’s spinal cord in order to evoke a target sensation. For example, bladder fullness will trigger the proposed intraspinal stimulator to deliver safe current pulses to the patient’s spinal cord to reenable the sensation of bladder fullness. The proposed probe will also sense the patient’s intention to urinate and relay the signal to a bladder stimulator to reenable patient’s control over their micturition. Nanopatterned stimulating electrodes will be fabricated and coupled with custom-designed complementary metal oxide semiconductor (CMOS) chips to deliver safe and spatially selective current pulses. The system aims to bypass the spinal cord injury to restore communication between the subject’s body and brain. The system will be validated in rodent nervous models and characterized for future human use.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
MD
Solicitation Number
NSF 23-515
Status
(Complete)
Last Modified 6/20/24
Period of Performance
6/15/24
Start Date
5/31/25
End Date
Funding Split
$275.0K
Federal Obligation
$0.0
Non-Federal Obligation
$275.0K
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2403910
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
H87NNXN7AHJ3
Awardee CAGE
8RAH5
Performance District
CA-30
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Modified: 6/20/24