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2224172

Project Grant

Overview

Grant Description
SBIR Phase I: A versatile nucleic acid collection and purification technology for wastewater-based epidemiology - The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to provide private and public stakeholders with new technological tools to better monitor and predict pandemics. This project is expected to modernize the tools used today by private and public laboratories to collect and purify pathogens, particularly human coronaviruses from community wastewater, for testing and diagnostic purposes.

The new technological tools are expected to simplify the workflow, reduce costs and time, and enable the prediction of COVID-19 outbreaks and other pandemics several weeks before observing clinical cases. Such early prediction would provide the public and government agencies with important data and sufficient time to take preventive measures. The technological products of this project are expected to empower the growing number of companies and laboratories offering wastewater-based epidemiology (WBE) services and help establish WBE as a routine, cost-effective, and reliable tool for public health monitoring.

This Small Business Innovation Research (SBIR) Phase I project will address a major technological barrier for the detection of viruses such as SARS-CoV-2 in wastewater. Commercially available nucleic acid collection and purification kits are designed for clinical samples with small volumes. These kits are not generally used for large wastewater volumes where the virus is present at low concentrations. As a result, current processes are time-consuming and result in the recovery of less than 30% of viruses and nucleic acids, significantly reducing the sensitivity.

The goal of this SBIR Phase I project is to demonstrate the feasibility of a novel virus and nucleic acid collection and purification technology from wastewater. Specifically, the project tasks aim at enhancing understanding of virus properties, particularly human coronaviruses in wastewater and their interactions with filter media. The project's innovative approach is to design a streamlined workflow that includes all the steps from sample collection to detection, in a single disposable cartridge containing novel filters with high affinity to viruses. This development is expected to enhance viral and nucleic acid recovery in wastewater to over 90%, while reducing costs. The developed tools will be independently tested and evaluated by third-party laboratories to confirm their performance.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Awarding / Funding Agency
Place of Performance
Saint Paul, Minnesota 55114-8658 United States
Geographic Scope
Single Zip Code
Related Opportunity
None
Analysis Notes
Amendment Since initial award the total obligations have increased 7% from $275,000 to $295,000.
Frontline Biotechnologies was awarded Project Grant 2224172 worth $295,000 from National Science Foundation in March 2023 with work to be completed primarily in Saint Paul Minnesota United States. The grant has a duration of 1 year and was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.

SBIR Details

Research Type
SBIR Phase I
Title
SBIR Phase I:A Versatile Nucleic Acid Collection and Purification Technology for Wastewater-Based Epidemiology
Abstract
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to provide private and public stakeholders with new technological tools to better monitor and predict pandemics. This project is expected to modernize the tools used today by private and public laboratories to collect and purify pathogens, particularly human coronaviruses from community wastewater, for testing and diagnostic purposes. The new technological tools are expected to simplify the workflow, reduce costs and time, and enable the prediction of COVID-19 outbreaks and other pandemics several weeks before observing clinical cases. Such early prediction would provide the public and government agencies with important data and sufficient time to take preventive measures. The technological products of this project are expected to empower the growing number of companies and laboratories offering wastewater-based epidemiology (WBE) services and help establish WBE as a routine, cost-effective and reliable tool for public health monitoring._x000D_ _x000D_ This Small Business Innovation Research (SBIR) Phase I project will address a major technological barrier for the detection of viruses such as SARS-CoV-2 in wastewater. Commercially available nucleic acid collection and purification kits are designed for clinical samples with small volumes.These kits are not generally used for large wastewater volumes where the virus is present at low concentrations. As a result, current processes are time-consuming, and result in the recovery of less than 30% of viruses and nucleic acids, significantly reducing the sensitivity. The goal of this SBIR Phase I project is to demonstrate the feasibility of a novel virus and nucleic acid collection and purification technology from wastewater. Specifically, the project tasks aim at enhancing understanding of virus properties, particularly human coronaviruses in wastewater and their interactions with filter media. The project’s innovative approach is to design a streamlined workflow that includes all the steps from sample collection to detection, in a single disposable cartridge containing novel filters with high affinity to viruses. This development is expected to enhance viral and nucleic acid recovery in wastewater to over 90%, while reducing costs. The developed tools will be independently tested and evaluated by third-party laboratories to confirm their performance._x000D_ _x000D_ This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BM
Solicitation Number
NSF 22-551

Status
(Ongoing)

Last Modified 7/28/23

Period of Performance
3/1/23
Start Date
2/29/24
End Date
99.0% Complete

Funding Split
$295.0K
Federal Obligation
$0.0
Non-Federal Obligation
$295.0K
Total Obligated
100.0% Federal Funding
0.0% Non-Federal Funding

Activity Timeline

Interactive chart of timeline of amendments to 2224172

Transaction History

Modifications to 2224172

Additional Detail

Award ID FAIN
2224172
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
XZAPQ4J49254
Awardee CAGE
8P6U9
Performance District
MN-04
Senators
Amy Klobuchar
Tina Smith

Budget Funding

Federal Account Budget Subfunction Object Class Total Percentage
Research and Related Activities, National Science Foundation (049-0100) General science and basic research Grants, subsidies, and contributions (41.0) $295,000 100%
Modified: 7/28/23