2222991
Project Grant
Overview
Grant Description
SBIR Phase I: A novel platform for virus enrichment and isolation - The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase I project will be the creation of a virus capture technology that may improve the reliability of diagnostic tools needed to detect viral infection in humans, animals, and plants.
The proposed device will be designed to be easy to use, portable, and cost-effective, and could accelerate virus detection, providing superior analytical and clinical performance. Early and accurate diagnosis of infectious diseases is critical to curbing the spread of viral infections, improving health outcomes, and reducing economic losses.
This technology is a platform potentially applicable to a wide range of target viruses and could be functional in different scenarios like virus surveillance, identification of emerging viruses, and detection of virus mutations. The proposed project seeks to validate the technical feasibility of this technology for direct virus detection methods such as polymerase chain reaction (PCR), immunoassay, and next-generation sequencing (NGS), to improve the virus-to-host ratio and allow for faster results.
The project aims to develop a portable sample processing platform that enables high-efficiency virus trapping and purification from field samples (from cotton swabs or tissue biopsy) without using antibodies. This technology uses carbon nanotube arrays to trap virus particles by size discrimination while segregating host contaminants.
This technology could be integrated into standard virus diagnostic protocols to achieve a faster, simpler, and more accurate diagnostics compared to traditional processes for virus sample preparation, such as ultracentrifugation and membrane filtration. Currently available state-of-the-art technologies present limitations in extracting pure virus particles from the host material, especially when the viral content is low, usually leading to false-negative results.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
The proposed device will be designed to be easy to use, portable, and cost-effective, and could accelerate virus detection, providing superior analytical and clinical performance. Early and accurate diagnosis of infectious diseases is critical to curbing the spread of viral infections, improving health outcomes, and reducing economic losses.
This technology is a platform potentially applicable to a wide range of target viruses and could be functional in different scenarios like virus surveillance, identification of emerging viruses, and detection of virus mutations. The proposed project seeks to validate the technical feasibility of this technology for direct virus detection methods such as polymerase chain reaction (PCR), immunoassay, and next-generation sequencing (NGS), to improve the virus-to-host ratio and allow for faster results.
The project aims to develop a portable sample processing platform that enables high-efficiency virus trapping and purification from field samples (from cotton swabs or tissue biopsy) without using antibodies. This technology uses carbon nanotube arrays to trap virus particles by size discrimination while segregating host contaminants.
This technology could be integrated into standard virus diagnostic protocols to achieve a faster, simpler, and more accurate diagnostics compared to traditional processes for virus sample preparation, such as ultracentrifugation and membrane filtration. Currently available state-of-the-art technologies present limitations in extracting pure virus particles from the host material, especially when the viral content is low, usually leading to false-negative results.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Funding Goals
THE GOAL OF THIS FUNDING OPPORTUNITY, "NSF SMALL BUSINESS INNOVATION RESEARCH (SBIR)/ SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS PHASE I", IS IDENTIFIED IN THE LINK: HTTPS://WWW.NSF.GOV/PUBLICATIONS/PUB_SUMM.JSP?ODS_KEY=NSF22551
Grant Program (CFDA)
Awarding Agency
Place of Performance
State College,
Pennsylvania
16801-2782
United States
Geographic Scope
Single Zip Code
Related Opportunity
22-551
Analysis Notes
Amendment Since initial award the End Date has been extended from 03/31/24 to 01/31/25.
Virolock Technologies Limited Liability Company was awarded
Project Grant 2222991
worth $274,459
from in July 2023 with work to be completed primarily in State College Pennsylvania United States.
The grant
has a duration of 1 year 6 months and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: A novel platform for virus enrichment and isolation
Abstract
The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase I project will be the creation of a virus capture technology that may improve the reliability of diagnostic tools needed to detect viral infection in humans, animals, and plants. The proposed device will be designed to be easy to use, portable, and cost-effective, and could accelerate virus detection, providing superior analytical and clinical performance. Early and accurate diagnosis of infectious diseases is critical to curbing the spread of viral infections, improving health outcomes, and reducing economic losses. This technology is a platform potentially applicable to a wide range of target viruses and could be functional in different scenarios like virus surveillance, identification of emerging viruses, and detection of virus mutations. _x000D_ _x000D_ The proposed project seeks to validate the technical feasibility of this technology for direct virus detection methods such as polymerase chain reaction (PCR), immunoassay, and next generation sequencing (NGS), to improve the virus to host ratio and allow for faster results. The project aims to develop a portable sample processing platform that enables high-efficiency virus trapping and purification from field samples (from cotton swabs or tissue biopsy) without using antibodies. This technology uses carbon nanotube arrays to trap virus particles by size discrimination while segregating host contaminants. This technology could be integrated into standard virus diagnostic protocols to achieve a faster, simpler, and more accurate diagnostics compared to traditional processes for virus sample preparation, such as ultracentrifugation and membrane filtration. Currently available state-of-the-art technologies present limitations in extracting pure virus particles from the host material, especially when the viral content is low, usually leading to false negative results._x000D_ _x000D_ This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BM
Solicitation Number
NSF 22-551
Status
(Complete)
Last Modified 12/18/24
Period of Performance
7/1/23
Start Date
1/31/25
End Date
Funding Split
$274.5K
Federal Obligation
$0.0
Non-Federal Obligation
$274.5K
Total Obligated
Activity Timeline
Transaction History
Modifications to 2222991
Additional Detail
Award ID FAIN
2222991
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
HFDXFEHD3ZY9
Awardee CAGE
7VEP1
Performance District
PA-15
Senators
Robert Casey
John Fetterman
John Fetterman
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Research and Related Activities, National Science Foundation (049-0100) | General science and basic research | Grants, subsidies, and contributions (41.0) | $274,459 | 100% |
Modified: 12/18/24