2143961
Project Grant
Overview
Grant Description
Sbir Phase I: Catechol Linker Oligosaccharide Combinations for Antimicrobial Surfaces -The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase 1 project is a decrease in the devastating effects of deep implant-related infections. The technology could result in advances to the clinical health and welfare of the American public by improving clinical outcomes and decreasing morbidity and mortality.
The technology addressed by this project may protect surgical implants, such as joint replacements and spinal fusion systems, from bacterial colonization and developing infections. This technology could significantly reduce the greater than $3 billion cost to the US healthcare system from implant-related infections. This antimicrobial technology could be used beyond medical applications for such things as food packaging to decrease foodborne diseases and more than double the shelf-life of certain food products.
Additionally, the linker technology developed through this project may be used to create super slick or self-cleaning surfaces with applications in the aerospace and marine industries, resulting in increased fuel efficiency and performance.
The project aims to develop a homogeneous, covalently bound, linker molecule attached to medical implant material (titanium alloy) upon which a quaternary ammonium-modified oligosaccharide will be subsequently attached. Oligosaccharides are known to be biocompatible, and quaternized oligosaccharides are highly potent antimicrobials. A treated medical implant could possess a powerfully antimicrobial surface so that, during surgery, any bacteria that encounter the surface will be killed. In this way, it is hoped that the avascular surface of the implant will not serve as a site for biofilm formation and growth and thus, reduce the incidence of perioperative infections.
The key to any successful surface modification is the quality of the chemical attachment of linkers and active molecules to that surface. Polyphenols and catechols such as dopamine are ideal candidates for investigation as these molecules are generally known for their facility in forming thin films onto a wide variety of surfaces. Using dopamine as a model system, catechol analogs will be electrochemically attached, and the resulting thin films analyzed for attachment, thickness, ease of further modification, and morphology.
Atomic force microscopy (AFM), UV/visible spectroscopy, soak/stress protocols, and microbiology will be used to gauge the success or failure of a thin film plus oligosaccharide combination.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
The technology addressed by this project may protect surgical implants, such as joint replacements and spinal fusion systems, from bacterial colonization and developing infections. This technology could significantly reduce the greater than $3 billion cost to the US healthcare system from implant-related infections. This antimicrobial technology could be used beyond medical applications for such things as food packaging to decrease foodborne diseases and more than double the shelf-life of certain food products.
Additionally, the linker technology developed through this project may be used to create super slick or self-cleaning surfaces with applications in the aerospace and marine industries, resulting in increased fuel efficiency and performance.
The project aims to develop a homogeneous, covalently bound, linker molecule attached to medical implant material (titanium alloy) upon which a quaternary ammonium-modified oligosaccharide will be subsequently attached. Oligosaccharides are known to be biocompatible, and quaternized oligosaccharides are highly potent antimicrobials. A treated medical implant could possess a powerfully antimicrobial surface so that, during surgery, any bacteria that encounter the surface will be killed. In this way, it is hoped that the avascular surface of the implant will not serve as a site for biofilm formation and growth and thus, reduce the incidence of perioperative infections.
The key to any successful surface modification is the quality of the chemical attachment of linkers and active molecules to that surface. Polyphenols and catechols such as dopamine are ideal candidates for investigation as these molecules are generally known for their facility in forming thin films onto a wide variety of surfaces. Using dopamine as a model system, catechol analogs will be electrochemically attached, and the resulting thin films analyzed for attachment, thickness, ease of further modification, and morphology.
Atomic force microscopy (AFM), UV/visible spectroscopy, soak/stress protocols, and microbiology will be used to gauge the success or failure of a thin film plus oligosaccharide combination.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Awardee
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
New Brunswick,
New Jersey
08901-3200
United States
Geographic Scope
Single Zip Code
Related Opportunity
None
Molecular Surface Technologies was awarded
Project Grant 2143961
worth $255,862
from National Science Foundation in May 2023 with work to be completed primarily in New Brunswick New Jersey United States.
The grant
has a duration of 1 year and
was awarded through assistance program 47.084 NSF Technology, Innovation, and Partnerships.
SBIR Details
Research Type
SBIR Phase I
Title
SBIR Phase I: Catechol Linker Oligosaccharide Combinations for Antimicrobial Surfaces
Abstract
The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase 1 project is a decrease in the devastating effects of deep implant-related infections.The technology could result in advances to the clinical health and welfare of the American public by improving clinical outcomes and decreasing morbidity and mortality. The technology addressed by this project may protect surgical implants, such as joint replacements and spinal fusion systems from bacterial colonization and developing infections. This technology could significantly reduce the greater than $3 billion cost to the US healthcare system from implant related infections. This antimicrobial technology could be used beyond medical applications for such things as food packaging to decrease foodborne diseases and more than double shelf-life of certain food products. Additionally, the linker technology developed through this project may be used to create super slick or self-cleaning surfaces with applications in the aerospace and marine industries resulting in increased fuel efficiency and performance._x000D_ _x000D_ The project aims to develop a homogeneous, covalently bound, linker molecule attached to medical implant material (titanium alloy) upon which a quaternary ammonium-modified oligosaccharide will be subsequently attached. Oligosaccharides are known to be biocompatible and quaternized oligosaccharides are highly potent antimicrobials. A treated medical implant could possess a powerfully antimicrobial surface so that, during surgery, any bacteria that encounter the surface will be killed. In this way, it is hoped that the avascular surface of the implant will not serve as a site for biofilm formation and growth and thus, reduce the incidence of perioperative infections. The key to any successful surface modification is the quality of the chemical attachment of linkers and active molecules to that surface. Polyphenols and catechols such as dopamine are ideal candidates for investigation as these molecules are generally known for their facility in forming thin films onto a wide variety of surfaces. Using dopamine as a model system, catechol analogs will be electrochemically attached, and the resulting thin films analyzed for attachment, thickness, ease of further modification, and morphology. Atomic Force Microscopy (AFM), UV/Visible spectroscopy, soak/stress protocols and microbiology will be used to gauge the success or failure of a thin film plus oligosaccharide combination._x000D_ _x000D_ This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Topic Code
BT
Solicitation Number
NSF 21-562
Status
(Complete)
Last Modified 5/19/23
Period of Performance
5/15/23
Start Date
4/30/24
End Date
Funding Split
$255.9K
Federal Obligation
$0.0
Non-Federal Obligation
$255.9K
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
2143961
SAI Number
None
Award ID URI
SAI EXEMPT
Awardee Classifications
Small Business
Awarding Office
491503 TRANSLATIONAL IMPACTS
Funding Office
491503 TRANSLATIONAL IMPACTS
Awardee UEI
EWD1WLQSR423
Awardee CAGE
8M1U6
Performance District
06
Senators
Robert Menendez
Cory Booker
Cory Booker
Representative
Frank Pallone
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Research and Related Activities, National Science Foundation (049-0100) | General science and basic research | Grants, subsidies, and contributions (41.0) | $255,862 | 100% |
Modified: 5/19/23