VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD (R01 - Clinical Trial Not Allowed)

Background
The Department of Health and Human Services, specifically the National Institutes of Health (NIH) and its components, the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), is issuing a funding opportunity to support research designed to advance fundamental understanding of basic disease-related molecular mechanisms of vascular contributions to cognitive impairment and dementia (VCID). The goal is to generate foundational knowledge in the emerging field of VCID that is needed for future development of interventions including for prevention and better clinical outcomes.

Grant Details
The grant aims to solicit applications focused on molecular mechanisms of small cerebral vessel diseases, including arteriolosclerosis, cerebral amyloid angiopathy (CAA), and atherosclerosis, that contribute to dementia diagnoses. Proposed research will use team-based and multi-faceted approaches to understand these small vessel disorders both cross-sectionally and over time, as well as their relationship to VCID phenotypic and clinical outcomes. The program will highlight Center Without Walls (CWOW) sharing of pre-publication ideas, data, methods, and results. The overall goal is to generate foundational knowledge in the emerging field of VCID that is needed for future development of interventions including for prevention and better clinical outcomes.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state and local governments, federally recognized Indian tribal governments, federal agencies, U.S. territories or possessions, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations, faith-based or community-based organizations. Foreign institutions are not eligible to apply.

Period of Performance
The period of performance for the grant will begin on February 1, 2024, with an earliest start date in July 2024. The maximum project period is up to 5 years.

Grant Value
NIH intends to commit up to $7,500,000 total costs per year to fund up to five NINDS awards. The maximum award budget is up to $1,000,000 direct costs per year for the proposed research program.