Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)

Background
The National Institute on Aging (NIA) invites R01 applications that propose human studies to better understand the mechanisms underlying compensatory gait, posture, and molecular changes that contribute to slower walking speed and increased metabolic cost of walking.

This funding opportunity aims to address a significant public health problem affecting over 25% of the population over 65 years of age, as mobility dysfunction severely limits independence and quality of life for older adults. The NIA encourages interdisciplinary collaborations and innovative approaches to explore interactions among multiple systems involved in gait biomechanics.

Grant Details
The grant focuses on understanding the mechanisms underlying compensatory gait and posture changes due to aging. Key areas of interest include:
1) mechanisms and effects of central nervous system changes;
2) neuromuscular changes;
3) skeletal muscle bioenergetics;
4) computational modeling and simulation;
5) changes in tissue structure and function (e.g., muscle-tendon complex, extracellular matrix).

The NIA encourages the use of innovative technologies such as computational modeling, imaging, sensor technologies, machine learning, and artificial intelligence to disentangle compensatory gait alterations with aging.

Eligibility Requirements
Eligible applicants include higher education institutions (public or private), nonprofits, for-profit organizations (including small businesses), local/state/federal governments, Indian/Native American tribal governments, foreign organizations, and other entities. Applicants are encouraged to include individuals from diverse backgrounds, including underrepresented racial and ethnic groups.

Period of Performance
The maximum project period is 5 years. The anticipated start date for funded projects is November 7, 2024.

Grant Value
NIA intends to commit $3,000,000 in fiscal year 2025 to fund up to 4 awards. Application budgets should reflect the actual needs of the proposed project and cannot exceed $500,000 per year in direct costs.