The Impact of Stressors on the Biological Mechanisms of Aging and Other Aging-Associated Outcomes in Experimental Model Systems (R61/R33 Clinical Trial Not allowed)

Background
The National Institutes of Health (NIH), specifically the National Institute on Aging (NIA), is issuing this funding opportunity to explore the impacts of stressors on the biological mechanisms of aging. This initiative aims to integrate stress exposure into aging research, addressing a significant gap in current studies that typically overlook the effects of stressors during adulthood. The overarching goal is to enhance our understanding of how stress influences aging processes and associated outcomes.

Grant Details
This funding opportunity invites applications for bi-phasic (R61/R33) projects aimed at examining the impacts of stress exposures on the hallmarks of aging using experimental model systems. The R61 phase focuses on identifying stressor(s) that affect aging when introduced in adulthood, with a duration of up to two years. Key milestones include demonstrating measurable effects of proposed stressors on aging hallmarks.

The R33 phase builds upon R61 findings to study the impact of these stressors on lifespan and healthspan over a maximum period of three years. Applicants may utilize in vitro systems, laboratory animals, or well-characterized animal populations. Stressors can be physical, social, or environmental and must be introduced during adulthood with clearly defined parameters.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local and state governments, tribal governments, and foreign organizations. Special encouragement is given to institutions serving underrepresented populations such as Hispanic-serving institutions and Historically Black Colleges and Universities (HBCUs). Individuals from diverse backgrounds are also encouraged to apply.

Period of Performance
The total project period can last up to five years, with a maximum of two years for the R61 exploratory phase and three years for the R33 implementation phase.

Grant Value
NIA intends to commit $3.25 million in FY 2025 to fund approximately 8 awards. The budget for the R61 phase cannot exceed $500,000 over two years (no more than $250,000 per year), while the R33 phase budget may not exceed $1.5 million over three years (no more than $500,000 per year).