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The Genesis Mission: Transforming Science and Energy with AI

ID: DE-FOA-0003612 • Type: Posted
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Description

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America's security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.

DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).

In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.

Overview

Category of Funding
Science and Technology and other Research and Development
Funding Instruments
Other
Grant Category
Discretionary
Cost Sharing / Matching Requirement
True
Source
On 3/17/26 the Office of Science posted grant opportunity DE-FOA-0003612 for The Genesis Mission: Transforming Science and Energy with AI with funding of $293.8 million. The grant will be issued under grant program 81.049 Office of Science Financial Assistance Program.

Timing

Posted Date
March 17, 2026, 12:00 a.m. EDT
Closing Date
Dec. 17, 2026, 12:00 a.m. EST Due in 199 Days
Last Updated
April 10, 2026, 9:22 a.m. EDT
Version
3
Archive Date
March 17, 2027

Eligibility

Eligible Applicants
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Award Sizing

Ceiling
$16,000,000
Floor
$500,000
Estimated Program Funding
$293,760,000
Estimated Number of Grants
Not Listed

Contacts

Contact
Michael S Zarkin Grants Management Specialist
Contact Phone
(301) 903-4946

Documents

Posted documents for DE-FOA-0003612

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