Tailoring HIV Curative Strategies to the Participant (UM1 Clinical Trial Not Allowed)

Background
The purpose of this Notice of Funding Opportunity (NOFO) is to support the development of clinical research platforms that will enable future clinical trials to determine whether combinations of HIV cure strategies can be effective when optimally tailored to the participants. The ultimate goal is for the results of such proof-of-concept clinical studies to inform the development and prioritization of more broad-based curative strategies that will be effective in all people living with HIV.

Grant Details
The overall goal is to develop clinical research platforms that will enable proof-of-concept studies to demonstrate that combinations of interventions specifically tailored to target a participant’s unique, intact, rebound-competent HIV reservoir, and that also complement their distinct immunologic profile, have the potential to be curative for HIV. The NOFO will support multidisciplinary teams to conduct coordinated basic and pre-clinical research to profile participants’ intact, rebound-competent HIV reservoirs and their immunologic profiles.

The scope includes basic and pre-clinical research as well as methods development and validation for optimal, rapid screening of potential participants in future clinical trials testing tailored HIV curative strategies. The total project period must be 5 years.

Eligibility Requirements
All organizations administering an eligible parent award may apply for a supplement under this NOFO. Eligible organizations include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, federal government agencies, U.S. territories or possessions, and other entities such as public housing authorities/Indian housing authorities or faith-based or community-based organizations.

Period of Performance
The project period must be 5 years.

Grant Value
$7,000,000 in FY 2025 to fund 2-3 awards. Application budgets are not expected to exceed $2 million in direct costs and need to reflect the actual needs of the proposed project.