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Supporting life-saving HIV services and related health systems in Zambia on a pathway to self-reliance under the President’s Plan for AIDS Relief (PEPFAR)

ID: CDC-RFA-JG-26-0179 • Type: Forecasted
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Description

The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $120,000,000 or Year 1, subject to the availability of funds.

This Notice of Funding Opportunity (NOFO) will provide support for life-saving services for HIV and related health conditions in Zambia, in cooperation with the Ministry of Health (MOH) and aligned with PEPFAR's goal of transition to host government self-reliance. You will also support the health systems necessary to ensure critical services are maintained, monitored, and implemented in a cost-effective and sustainable manner. Activities within the NOFO will provide support to the host government at the provincial, district, facility, and/or community levels to oversee, monitor, and implement evidence-based activities. Clinical support for HIV will focus on treatment, laboratory, adherence support, and retention in care. Health systems support will focus on sustainability and host government self-reliance, maintaining patient and program monitoring systems, and human resources for health.

Background
This Notice of Funding Opportunity (NOFO) is issued by the Centers for Disease Control and Prevention (CDC) to support life-saving services for HIV and related health conditions in Zambia. The initiative aligns with the President’s Plan for AIDS Relief (PEPFAR) and aims to transition to host government self-reliance, working in cooperation with the Ministry of Health (MOH).

Grant Details
The grant will provide support for critical HIV services and health systems necessary for maintaining, monitoring, and implementing these services in a cost-effective and sustainable manner. Key activities include:

1. Clinical support focusing on treatment, laboratory services, adherence support, and retention in care.

2. Health systems support aimed at sustainability and host government self-reliance, including maintaining patient and program monitoring systems and enhancing human resources for health.

Eligibility Requirements
Eligible applicants include organizations that can demonstrate experience in providing HIV-related health services and have a proven track record of working with governmental health agencies.

Period of Performance
The period of performance will be determined based on the availability of funds but is expected to span multiple years as part of a long-term strategy to enhance health systems in Zambia.

Grant Value
The total value of the grant is approximately $120,000,000 for Year 1, subject to the availability of funds. There is no specified award ceiling for individual grants within this funding opportunity.

Place of Performance
The grant activities will be performed in Zambia, specifically at provincial, district, facility, and community levels.
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Overview

Agency
Centers for Disease Control and Prevention (CDC) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.067 - Global AIDS
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 10/16/25 Centers for Disease Control and Prevention forecasted grant opportunity CDC-RFA-JG-26-0179 for Supporting life-saving HIV services and related health systems in Zambia on a pathway to self-reliance under the President’s Plan for AIDS Relief (PEPFAR). The grant will be issued under grant program 93.067 Global AIDS. It is expected that 4 total grants will be made.

Timing

Forecast Posted Date
Oct. 16, 2025, 12:00 a.m. EDT
Est. Application Posting Date
Dec. 2, 2025, 12:00 a.m. EST
Est. Synopsis Response Date
Feb. 17, 2026, 12:00 a.m. EST Forecasted
Last Updated
Oct. 16, 2025, 9:15 a.m. EDT
Version
1
Archive Date
March 19, 2026

Eligibility

Eligible Applicants
Public housing authorities/Indian housing authorities
State governments
City or township governments
Native American tribal governments (Federally recognized)
Special district governments
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
For profit organizations other than small businesses
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
Public and State controlled institutions of higher education

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
Not Provided
Estimated Number of Grants
4

Contacts

Contact
DGHT NOFOs
Contact Email
pepfarfoas@cdc.gov

Documents

Posted documents for CDC-RFA-JG-26-0179

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