Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

Background
The Stimulating Hematology Investigation: New Endeavors (SHINE) program is intended to promote innovative, high-quality nonmalignant hematology research relevant to the missions of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). This program invites investigator-initiated research project grant applications (R01s) in specific areas of basic and early translational hematology research, supporting growth in the nonmalignant hematology research domain.

The program aims to catalyze discoveries in basic molecular and cellular biology that provide new insights into the pathogenesis, prevention, detection, and potential treatment of nonmalignant hematologic diseases.

Grant Details
The SHINE program supports innovative research in various areas including metabolic modulators of hematopoiesis, remodeling the hematopoietic stem cell niche, biology of erythrocyte maturation, hematopoietic response to stress, and modeling the bone marrow microenvironment after conditioning or in nonmalignant hematologic diseases.

The program encourages interdisciplinary collaborations and aims to attract new investigators into basic and translational hematology research. A Plan for Enhancing Diverse Perspectives (PEDP) is required as part of the application process.

Eligibility Requirements
Eligible applicants include higher education institutions (public/state controlled, private), nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), local governments, state governments, county governments, city or township governments, special district governments, Indian/Native American tribal governments (federally recognized and others), federal agencies, U.S. territories or possessions, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, and regional organizations. Foreign organizations are not eligible to apply.

Period of Performance
The maximum project period is 5 years. The last application due date for new R01 applications is February 5, 2025.

Grant Value
NIH intends to fund an estimated 5–8 awards with a total funding amount of $2,500,000 for FY 2025. Application budgets are not limited but must reflect the actual needs of the proposed project.