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Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

ID: RFA-RM-28-015 • Type: Forecasted
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Description

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative.

The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.

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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.310 - Trans-NIH Research Support
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 9/14/26 the National Institutes of Health forecasted grant opportunity RFA-RM-28-015 for Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed). The grant will be issued under grant program 93.310 Trans-NIH Research Support. It is expected that one grant will be made.

Timing

Forecast Posted Date
Est. Application Posting Date
Est. Synopsis Response Date
Forecasted
Last Updated
Version
1

Eligibility

Eligible Applicants
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
City or township governments
State governments
County governments
Special district governments
Native American tribal governments (Federally recognized)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Independent school districts
Public and State controlled institutions of higher education
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
Not Provided
Estimated Number of Grants
1

Contacts

Contact
SMaHT Program
Contact Email
smaht@od.nih.gov

Documents

Posted documents for RFA-RM-28-015

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