Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed)

Background
The National Longitudinal Study of Adolescent to Adult Health (Add Health) is a longitudinal cohort study initiated by the National Institutes of Health (NIH) aimed at understanding the life course factors influencing aging and Alzheimer's disease (AD) and related dementias (ADRD). This study focuses on individuals born between 1976 and 1982, who were first interviewed as adolescents. As these respondents reach midlife, this funding opportunity aims to continue core study activities while enhancing Add Health as a resource for understanding health disparities related to aging.

Grant Details
The grant will support the continuation of core activities including:
- Re-interviewing eligible participants using a mixed-mode survey design that maintains population representation and assesses midlife factors relevant to dementia risk.
- Conducting in-home health visits with venous blood collection.
- Assaying blood for biomarkers associated with aging and AD/ADRD risk.
- Performing comprehensive assessments of cognitive, physical, and sensory functions.
- Updating mortality information from administrative data sources.
- Cleaning, documenting, disseminating, and archiving both public and restricted access data.
Additionally, an enhancement activity will involve expanding assays for biomarkers relevant to aging processes.

Eligibility Requirements
Only the University of North Carolina at Chapel Hill is eligible to apply for this funding opportunity as it is a single source cooperative agreement intended for this institution due to its unique knowledge and access to the Add Health sample frame.

Period of Performance
The maximum project period is five years.

Grant Value
The NIH intends to commit an estimated total of $13,100,000 to fund one award under this opportunity.

Place of Performance
The grant will be performed at the University of North Carolina at Chapel Hill.