Single Source for Continuation of the Accelerating Medicines Partnership (AMP) in Common Metabolic Diseases (CMD) Knowledge Portal (U01 Research Project (Cooperative Agreement) Clinical Trial not allowed)

Background
The National Institutes of Health (NIH), through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), is issuing a non-competitive Notice of Funding Opportunity (NOFO) to fund a single award to the Broad Institute, Inc. This initiative is part of the Accelerating Medicines Partnership in Common Metabolic Diseases Knowledge Portal (AMP CMD KP). It aims to develop new models for identifying and validating biological targets for drug discovery and biomarkers.

The AMP CMD program collaborates with pharmaceutical companies and nonprofit organizations to enhance understanding of common metabolic diseases (CMDs) such as obesity, diabetes, and cardiovascular disease. The goal of this NOFO is to continue the development and maintenance of the AMP CMD KP, which serves as a comprehensive resource for data related to CMDs.

Grant Details
The awarded institution will be responsible for:
1) Continuing the development and maintenance of the AMP CMD Knowledge Portal;
2) Expanding datasets and traits related to CMDs;
3) Importing additional data types;
4) Deploying analytical and visualization tools;
5) Increasing utility for a diverse user base;
6) Developing a framework for independent sustainability.

The AMP CMD KP will serve as a curated repository, analytical platform, and portal for publicly available data on CMDs. It will facilitate research that leads to potential biomarkers and therapeutic targets. The project will not generate new data but will aggregate existing genomic information.

Eligibility Requirements
Only the Broad Institute, Inc., the current awardee institution under RFA-DK-19-505, is eligible to apply. Non-domestic entities are not eligible unless they are components of U.S. organizations. Only one application per institution is allowed.

Period of Performance
The maximum project period is five years.

Grant Value
NIDDK intends to commit $15 million total costs over five years for one award, with individual budgets not exceeding $2 million in direct costs per year.

Place of Performance
The grant will be performed at the Broad Institute, Inc.