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Single Source: Bench to Bassinet Congenital Heart disease Advancing New understanding in GEnomics Cohort (B2B CHANGE Cohort) Data Coordinating Center (U01 Clinical Trial Not Allowed)

ID: RFA-HL-26-007 • Type: Posted
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Description

The B2B Pediatric Cardiac Genomics Consortium (PCGC) (http://www.benchtobassinet.com/) will evolve to the B2B CHANGE Cohort (Congenital Heart disease Advancing New understanding in GEnomics). The B2B CHANGE Cohorts mission will be to conduct long-term clinical follow up on participants from the original PCGC Cohort, to perform deeper cohort phenotyping and to support investigators in applying for funding to conduct multi-center, collaborative ancillary studies to further understand how genetic variants relate to clinical outcomes. The Administrative Coordinating Center (ACC) will serve to lead and advance data and resource management and sharing, and coordinate critical data collection and participant outreach efforts at the clinical research sites. The ACC will work in a collaborative fashion with site PIs, as well as the broader congenital heart disease (CHD) research community.
Background
The Bench to Bassinet Pediatric Cardiac Genomics Consortium (PCGC) is evolving into the B2B CHANGE Cohort. This initiative aims to advance understanding of congenital heart disease (CHD) through long-term clinical follow-up and deeper cohort phenotyping. The National Heart, Lung, and Blood Institute (NHLBI) is issuing a single-source cooperative agreement to Cincinnati Children's Hospital Medical Center to transition the existing Administrative Coordinating Center into a Data Coordinating Center for the B2B CHANGE Cohort. This initiative seeks to leverage existing data platforms and enhance collaborative research efforts in CHD.

Grant Details
The Data Coordinating Center (CC) will be responsible for:

1. Operations: Logistical support for meetings, document maintenance, collaboration with Pediatric Heart Network, and public engagement through a website.

2. Cohort Engagement: Organizing recontact efforts and continued enrollment of diverse participants.

3. Protocol Development: Supporting collaborative research protocols and monitoring adherence.

4. Core Facilities and Data Management: Maintaining a data repository, ensuring data accessibility, and managing biospecimen collection.

5. Governance: Establishing a Steering Committee for oversight of cohort activities and decision-making on ancillary studies.

Eligibility Requirements
Only Cincinnati Children's Hospital Medical Center is eligible to apply for this funding opportunity as it is a single-source award.

Period of Performance
The maximum project period is 6 years, with funding anticipated annually from FY2026 through FY2031.

Grant Value
NHLBI intends to commit an estimated total cost of up to $6,416,600 annually for this award, with application budgets not exceeding $4,010,000 in direct costs per year.

Place of Performance
The grant will be performed at Cincinnati Children's Hospital Medical Center.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.837 - Cardiovascular Diseases Research
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 1/10/25 the National Institutes of Health posted grant opportunity RFA-HL-26-007 for Single Source: Bench to Bassinet Congenital Heart disease Advancing New understanding in GEnomics Cohort (B2B CHANGE Cohort) Data Coordinating Center (U01 Clinical Trial Not Allowed). The grant will be issued under grant program 93.837 Cardiovascular Diseases Research.

Timing

Posted Date
Jan. 10, 2025, 12:00 a.m. EST
Closing Date
March 18, 2025, 12:00 a.m. EDT Past Due
Last Updated
Jan. 10, 2025, 12:34 p.m. EST
Version
1
Archive Date
April 23, 2025

Eligibility

Eligible Applicants
Public and State controlled institutions of higher education
Additional Info
Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Only the following applicant is eligible to apply for this single source funding: Cincinnati Children's Hospital Medical Center.

Award Sizing

Ceiling
$4,010,000
Floor
Not Listed
Estimated Program Funding
Not Provided
Estimated Number of Grants
Not Listed

Contacts

Contact
National Institutes of Health
Contact Email
grantsinfo@nih.gov
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-007.html
Additional Information Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-007.html

Documents

Posted documents for RFA-HL-26-007

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