Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed)

The National Cancer Institutes (NCI) Cancer Systems Biology Consortium (CSBC, https://csbconsortium.org/) supports the application of systems biology approaches to cancer research and includes U01 Research Projects and, through this FOA, U54 Research Centers. These multi-project Centers should address challenges in basic cancer biology that would benefit from a coordinated systems biology approach and should coalesce around a well-defined overarching scientific theme pursued through two or three research projects. The research projects should be driven by a specific hypothesis and incorporate iterative cycles of quantitative experimentation, analysis, modeling, and validation in a disease-relevant context. Centers will include an interdisciplinary research team including quantitative and cancer biology expertise, administrative management, optional shared resource cores, and an Outreach core that support the overall Center research theme. Each Center will make sharing interoperable datasets and community accessible tools a priority with the support of a multi-consortium U24 Coordinating Center (being solicited under RFA-CA-21-049), actively collaborate within and outside the consortium, and support a welcoming and diverse research community at the Center and Consortium level.