Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness (ReVAMPP) Centers for Flaviviridae and Togaviridae (U19 Clinical Trial Not Allowed)

Background
The National Institute of Allergy and Infectious Diseases (NIAID) supports complementary research programs to understand, control and prevent viral diseases and related pandemics. As part of pandemic preparedness planning, this Funding Opportunity Announcement (FOA) solicits applications to establish comprehensive, cooperative basic and translational research centers to advance scientific knowledge needed to develop vaccines and monoclonal antibodies (mAbs) for prototype viral pathogens within virus families that have pandemic potential.

Grant Details
The objective of this FOA is to establish multidisciplinary research Centers to be part of the highly collaborative ReVAMPP Network focused on in-depth basic and translational research on prototype members of certain virus families that have the potential to emerge as pandemic pathogens, namely Flaviviridae and Togaviridae. The major goal of these Centers will be to develop vaccine strategies for prototype pathogens that can be applied to other closely related family members based on shared functional and structural properties.
Each Center will encompass a multi-project multidisciplinary research program that employs innovative virology, structural biology, and immunology to identify strategies for vaccine design.
Each Center will collaborate across the ReVAMPP Network through the sharing of data, reagents, protocols, and animal models to facilitate advancement toward pandemic preparedness for all virus families.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, county governments, city or township governments, special district governments, Indian/Native American Tribal Governments (Federally Recognized), U.S. Territory or Possession, foreign institutions, and eligible agencies of the Federal Government. Foreign entities are also eligible to apply.

Period of Performance
The project period should be determined by the scope of the proposed project but should not exceed 5 years.

Grant Value
NIAID intends to commit approximately $15-30M in FY2024 to fund 1-2 awards. The application budgets are not expected to exceed $10M direct costs/year.