Renewal of the Interventions Testing Program (U01 Clinical Trial Not Allowed)

Background
This Funding Opportunity Announcement (FOA) calls for the renewal and further development of the Interventions Testing Program (ITP). The ITP tests potential intervention strategies that may delay aging in mammals under standardized conditions. The interventions' effects on aging are measured by lifespan extension and/or delayed onset/severity of late life pathologies. The ITP uses lifespan as a primary outcome.

Secondary outcomes currently include geropathology assessment at 22 months of age and pathology at time of death, functional phenotypes (e.g., measures of strength) and measurements of animal vitals (e.g., weight) at intervals across the lifespan.

Grant Details
The FOA invites renewal applications to the Interventions Testing Program. The program aims to continue testing compounds for effects on lifespan, expand geropathology assessment, introduce transcriptomics analyses, expand tissue collection for selected compounds, and develop a new system for distributing tissues collected by the ITP.

Eligibility Requirements
Only the current awardees of the ITP funded through RFA-AG-19-030 are eligible to apply to this FOA. Eligible organizations include higher education institutions, nonprofits other than institutions of higher education, for-profit organizations, state governments, county governments, city or township governments, special district governments, Indian/Native American tribal governments (federally recognized), U.S. territory or possession, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, and regional organizations.

Period of Performance
The maximum project period is 5 years.

Grant Value
$4.9 million in FY 2024 to fund 3 awards. Direct costs for awards may not exceed $3 million per year for the entire consortium.