Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

Background
The National Institute of Mental Health (NIMH) is part of the Department of Health and Human Services. It aims to transform the understanding and treatment of mental illnesses through research. This grant opportunity, titled 'Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes,' focuses on pilot projects that evaluate the effectiveness of therapeutic and service delivery interventions for managing mental health conditions in the post-acute phase. The goal is to generate preliminary data that can inform larger-scale effectiveness trials.

Grant Details
The grant supports pilot effectiveness research aimed at evaluating therapeutic and service delivery interventions for post-acute management of mental health conditions. Key tasks include:
1. Evaluating the feasibility, tolerability, acceptability, safety, and potential effectiveness of proposed interventions.
2. Assessing whether the intervention engages target mechanisms presumed to underlie intervention effects.
3. Generating preliminary data necessary for larger-scale effectiveness trials.
4. Addressing disparities in post-acute care outcomes for underserved groups.
5. Exploring various strategies such as continuation treatments, maintenance therapies, technology-assisted approaches, and integration into non-traditional settings.

Eligibility Requirements
Eligible applicants include higher education institutions (public or private), nonprofits, for-profit organizations (including small businesses), local/state governments, tribal governments, federal agencies, independent school districts, public housing authorities, faith-based organizations, and foreign entities. Individuals from diverse backgrounds are encouraged to apply.

Period of Performance
The total project period may not exceed three years with direct costs limited to $750,000 over this period; no more than $250,000 in direct costs is allowed in any single year.

Grant Value
The total value of the grant is up to $750,000 over a maximum project period of three years.