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Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials

ID: PAR-26-092 • Type: Forecasted
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Description

The National Institute on Drug Abuse seeks to support pilot and feasibility studies in preparation for efficacy, effectiveness and/or services research trials. Topics may include:1) developing interventions to prevent substance use, misuse or progression to disorder, 2) substance use prevention, treatment or recovery services research, including comorbid pain, medical and mental health disorders, 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.

Projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation; assessing intervention or service model acceptability and feasibility; and development of measures, materials, or methods for the future trial. Preliminary data is not required. A well-defined theory of change or logic model is expected. Applicants must engage relevant end users in study design, execution, and interpretation (e.g., policymakers, state and local decision makers, practitioners, individuals with lived/living experience, families, youth, and community members).

Applications are not being solicited at this time. This notice is to allow applicants time to develop collaborations and responsive projects. Grant authorities that allow this forecast are 42 U.S.C. 241 and 284.

Background
The National Institute on Drug Abuse (NIDA) aims to support pilot and feasibility studies that prepare for efficacy, effectiveness, and/or services research trials. The goal of this grant opportunity is to develop interventions aimed at preventing substance use and HIV, addressing comorbid conditions, and enhancing stakeholder partnerships.

Grant Details
The grant will support projects that may include:
1) Developing interventions to prevent substance use, misuse, or progression to disorder;
2) Research on substance use prevention, treatment, or recovery services, including those related to comorbid pain and mental health disorders;
3) HIV eradication research focusing on implementation science and prevention in substance use settings.

Activities may involve intervention development/adaptation, assessing the acceptability and feasibility of intervention or service models, and developing measures or methods for future trials. A well-defined theory of change or logic model is expected. Engagement with relevant end users in study design and execution is required.

Eligibility Requirements
Applicants must engage relevant stakeholders such as policymakers, practitioners, individuals with lived experience, families, youth, and community members in the study design and execution. Preliminary data is not required for application.

Period of Performance
The period of performance typically would align with the timeline necessary for conducting pilot studies.

Grant Value
The total value of the grant opportunity is not explicitly stated in the document. Individual grant awards will likely vary based on project scope and budget requirements.

Overview

Category of Funding
Health
Funding Instruments
Grant
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 1/26/26 the National Institutes of Health forecasted grant opportunity PAR-26-092 for Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials. The grant will be issued under grant program 93.279 Drug Abuse and Addiction Research Programs.

Timing

Forecast Posted Date
Jan. 26, 2026, 12:00 a.m. EST
Est. Application Posting Date
July 2, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
Oct. 2, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Jan. 26, 2026, 8:25 a.m. EST
Version
1

Eligibility

Eligible Applicants
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
County governments
Special district governments
Independent school districts
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Private institutions of higher education
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Contacts

Contact
NIDA DESPR Program Staff
Email Description
Division of Epidemiology Services and Prevention Research

Documents

Posted documents for PAR-26-092

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