NIH Research Project Grant (Parent R01 Clinical Trial Required)

Background
The NIH Research Project Grant (Parent R01 Clinical Trial Required) is issued by the National Institutes of Health (NIH). It aims to support discrete, specified projects in areas aligned with the scientific missions of participating NIH Institutes and Centers (ICs). This funding opportunity requires that at least one clinical trial be proposed, emphasizing the importance of clinical research in advancing health-related knowledge and practices.

Grant Details
The grant supports a discrete, specified project that must include at least one clinical trial. The proposed project should align with the programmatic interests of one or more participating NIH ICs. The NIH defines a clinical trial as a research study where human subjects are assigned to interventions to evaluate effects on health-related outcomes. Applications must propose clinical trials that may include mechanistic studies aimed at understanding biological or behavioral processes. The maximum project period is five years, and application budgets should reflect actual project needs.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local and state governments, tribal governments, and foreign organizations. Individuals from diverse backgrounds are encouraged to apply. Specific institutions such as Hispanic-serving institutions and Historically Black Colleges and Universities are always encouraged to apply.

Period of Performance
The period of performance for the grant can extend up to five years depending on the scope of the proposed project.

Grant Value
The total value of the grant is contingent upon NIH appropriations and the submission of meritorious applications. Application budgets must reflect actual needs.