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NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)

ID: RFA-RM-24-004 • Type: Posted

Description

The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIHs Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome in all topic areas relevant to the broad mission of NIH, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund. Towards the objective of funding the best possible science, the Office of Strategic Coordination and the Center for Scientific Review are piloting a process for initial peer review of applications received in response to this FOA in which the identity of the investigators and institutions are withheld until the last phase of review. Instructions for anonymizing components of the application are given in Section IV and must be carefully followed. A description of the review process is given in Section V.
Background
The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. It is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

Grant Details
The award supports collaborative investigative teams or individual scientists who propose unusually bold and innovative research projects, which, if successful, would have a major impact in a broad area of relevance to the NIH. Projects must have the potential to create or overturn fundamental scientific paradigms through novel concepts or perspectives, transform the way research is conducted through the development of novel tools or technologies, or lead to major improvements in health through the development of highly innovative diagnostic, therapeutic, or preventive strategies. The application focuses on the importance of the problem, the novelty of the hypothesis and/or the proposed methodology, and the magnitude of the potential impact rather than on preliminary data or experimental details.

Eligibility Requirements
All organizations administering an eligible parent award may apply for a supplement under this NOFO. Eligible organizations include higher education institutions (public/state controlled institutions of higher education, private institutions of higher education), nonprofits (with 501(c)(3) IRS status), for-profit organizations (small businesses and other than small businesses), local governments, state governments, county governments, city or township governments, special district governments, Indian/Native American tribal governments (federally recognized), U.S. territory or possession, independent school districts, public housing authorities/Indian housing authorities, native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations.

Period of Performance
The maximum project period is five years.
The open date for submission is August 03, 2024.
The earliest start date is September 03, 2024.

Grant Value
NIH intends to commit approximately $8 million in FY 2025 and make approximately 7 awards.
Application budgets are not limited but must be commensurate with the scope of the proposed research.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.310 - Trans-NIH Research Support
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 3/18/24 the National Institutes of Health posted grant opportunity RFA-RM-24-004 for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional). The grant will be issued under grant program 93.310 Trans-NIH Research Support.

Timing

Posted Date
March 18, 2024, 12:00 a.m. EDT
Closing Date
Sept. 3, 2024, 12:00 a.m. EDT Due in 37 Days
Last Updated
March 18, 2024, 2:40 p.m. EDT
Version
1
Archive Date
Oct. 9, 2024

Eligibility

Eligible Applicants
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
Native American tribal governments (Federally recognized)
State governments
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Independent school districts
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Additional Info
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Contacts

Contact
National Institutes of Health
Contact Email
grantsinfo@nih.gov
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-004.html
Additional Information Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-004.html

Documents

Posted documents for RFA-RM-24-004

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