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NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)

ID: RFA-RM-25-003 • Type: Posted
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Description

Posted: June 16, 2025, 12:00 a.m. EDT
The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIHs Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome in all topic areas relevant to the broad mission of NIH, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund. Towards the objective of funding the best possible science, the Office of Strategic Coordination and the Center for Scientific Review are piloting a process for initial peer review of applications received in response to this FOA in which the identity of the investigators and institutions are withheld until the last phase of review. Instructions for anonymizing components of the application are given in Section IV and must be carefully followed. A description of the review process is given in Section V.
Posted: May 12, 2025, 12:00 a.m. EDT
Posted: May 12, 2025, 12:00 a.m. EDT
Posted: May 12, 2025, 12:00 a.m. EDT
Posted: May 12, 2025, 12:00 a.m. EDT
Background
The NIH Directors Transformative Research Award Program, part of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund, supports individual scientists or groups proposing bold and groundbreaking research that has the potential to create new scientific paradigms or develop transformative technologies. The program encourages applications from diverse backgrounds and institutions across all geographic locations, aiming to fund innovative research relevant to the broad mission of NIH.

Grant Details
The NIH Director's Transformative Research Award supports collaborative investigative teams or individual scientists proposing unusually bold and innovative research projects. Projects must demonstrate a compelling potential to produce a major impact in a broad area relevant to NIH. Applications are encouraged in all research areas including behavioral, social, biomedical, applied, and formal sciences. No preliminary data are required; instead, emphasis is placed on the significance of the problem, novelty of the hypothesis or methodology, and potential impact. The maximum project period is five years with no budget limits but must be commensurate with the scope of research. NIH intends to commit approximately $8 million in FY 2026 for about 7 awards.

Eligibility Requirements
Eligible applicants include higher education institutions (public/state-controlled and private), nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), local governments, state governments, tribal governments (federally recognized and others), independent school districts, public housing authorities, faith-based organizations, regional organizations, and foreign organizations. Non-domestic components of U.S. organizations are not eligible. All applicants must have completed necessary registrations prior to application submission.

Period of Performance
The maximum project period for awarded grants is five years.

Grant Value
NIH intends to commit approximately $8 million in FY 2026 with an anticipated number of about 7 awards. Application budgets are not limited but should align with the proposed research scope.

Place of Performance
The grant opportunity does not specify particular geographic locations; it encourages applications from institutions across all geographic locations.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.310 - Trans-NIH Research Support
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 6/16/25 the National Institutes of Health posted grant opportunity RFA-RM-25-003 for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional). The grant will be issued under grant program 93.310 Trans-NIH Research Support.

Timing

Posted Date
June 16, 2025, 12:00 a.m. EDT
Closing Date
Sept. 3, 2025, 12:00 a.m. EDT Past Due
Last Updated
June 16, 2025, 12:14 p.m. EDT
Version
1
Archive Date
Oct. 9, 2025

Eligibility

Eligible Applicants
Independent school districts
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
Special district governments
For profit organizations other than small businesses
Private institutions of higher education
Small businesses
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Info
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Contacts

Contact
National Institutes of Health
Contact Email
grantsinfo@nih.gov
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-25-003.html
Additional Information Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-25-003.html

Documents

Posted documents for RFA-RM-25-003

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