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NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)

ID: NOT-RM-25-010 • Type: Forecasted

Description

The Office of Strategic Coordination (Common Fund) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the NIH Director's Transformative Research Award, part of the High-Risk, High-Reward Research program. The NIH Director's Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Preliminary data and detailed experimental plans are not requested or required.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful and responsive projects. Investigators of exceptional creativity with a high-risk, high-impact proposal are encouraged to begin to consider applying for this new NOFO. This NOFO will utilize the R01 activity code.

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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.310 - Trans-NIH Research Support
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 5/12/25 the National Institutes of Health forecasted grant opportunity NOT-RM-25-010 for NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) with funding of $8.0 million. The grant will be issued under grant program 93.310 Trans-NIH Research Support. It is expected that 7 total grants will be made.

Timing

Forecast Posted Date
May 12, 2025, 12:00 a.m. EDT
Est. Application Posting Date
June 20, 2025, 12:00 a.m. EDT
Est. Synopsis Response Date
Sept. 3, 2025, 12:00 a.m. EDT Forecasted
Last Updated
May 12, 2025, 12:32 p.m. EDT
Version
1

Eligibility

Eligible Applicants
Small businesses
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Independent school districts
For profit organizations other than small businesses
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
County governments
Public housing authorities/Indian housing authorities

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$8,000,000
Estimated Number of Grants
7

Contacts

Contact
Patricia Labosky, Ph.D. Office of the Director (OD)
Contact Email
transformative_awards@mail.nih.gov   Profile

Documents

Posted documents for NOT-RM-25-010

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