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NIH Director’s Early Independence Awards (DP5 Clinical Trial Optional)

ID: NOT-RM-25-011 • Type: Forecasted
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Description

The Office of Strategic Coordination (Common Fund) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the NIH Director's Early Independence Award, part of the High-Risk, High-Reward Research program. The NIH Director's Early Independence Award supports rigorous and promising investigators who wish to pursue independent research soon after completion of their terminal doctoral degree or post-graduate clinical training, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. Applications in all topics relevant to the broad mission of NIH are welcome, and preliminary data are not required.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful and responsive projects. Promising, newly graduated scientists with the maturity and skills needed to successfully launch an independent research program are encouraged to begin to consider applying for this new NOFO. This NOFO will utilize the DP5 (Clinical Trial Optional) activity code.

Overview

Category of Funding
Health
Funding Instruments
Grant
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 8/5/25 the National Institutes of Health forecasted grant opportunity NOT-RM-25-011 for NIH Director’s Early Independence Awards (DP5 Clinical Trial Optional) with funding of $5.1 million. The grant will be issued under grant program 93.310 Trans-NIH Research Support. It is expected that 9 total grants will be made.

Timing

Forecast Posted Date
Aug. 5, 2025, 12:00 a.m. EDT
Est. Application Posting Date
Sept. 10, 2025, 12:00 a.m. EDT
Est. Synopsis Response Date
Oct. 10, 2025, 12:00 a.m. EDT Forecasted
Last Updated
Aug. 14, 2025, 11:11 a.m. EDT
Version
2
Archive Date
Aug. 15, 2025

Eligibility

Eligible Applicants
Private institutions of higher education
Small businesses
County governments
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Independent school districts
Public and State controlled institutions of higher education
Additional Info
Only single PD/PI applications are allowed; PD/PI must complete terminal doctoral degree or clinical training sometime between May 1, 2024, and September 30, 2026;Must be in non-independent research position at time of application;Limit of 2 applications per institution;Requires significant institutional commitment

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$5,100,000
Estimated Number of Grants
9

Contacts

Contact
Becky Miller, Ph.D. Office of the Director (OD)

Documents

Posted documents for NOT-RM-25-011

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