NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

Background
The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership in research, training, and education to promote the prevention and treatment of heart, lung, blood, and sleep disorders. The NHLBI's mission encompasses many common diseases such as heart disease and chronic respiratory diseases, which are leading causes of death in the US and worldwide. The NHLBI also supports research on rare and complex diseases.

The TransOmics for Precision Medicine (TOPMed) program was established to generate large-scale genomics data for the research community to enable the study of molecular mechanisms underlying HLBS disorders. This NOFO invites applications to utilize TOPMed resources to generate integrated genetic and multi-omics data aimed at understanding HLBS disorders at molecular levels.

Grant Details
This NOFO invites applications to access TOPMed capacity to generate a large volume of integrated genetic and multi-omics data. The genomic data and related phenotypic data will be deposited in public NIH-designated controlled-access databases such as dbGaP and NHLBI's BioData Catalyst (BDC). Applicants are expected to participate in TOPMed data-sharing, integrate existing high-quality biospecimens from well-phenotyped human subjects, and focus on generating whole genome sequencing (WGS) data. Applications should address specific knowledge gaps relevant to HLBS disorders, including common diseases and rare diseases like Sickle Cell disease. All omics data must be shared with the broader research community through designated databases.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, tribal governments, foreign organizations, and other entities as specified in the eligibility section. Applicants must ensure that all human subjects used in their applications are appropriately consented for data-sharing.

Period of Performance
The maximum project period is 3 years.

Grant Value
No funding will be provided under this NOFO; it is a resource access award with no budget applicable.