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NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)

ID: RFA-CA-27-006 • Type: Posted
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Description

Posted: May 21, 2026, 12:00 a.m. EDT
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial and other human subject research study results through accrual in a variety of community settings. The purpose of NCORP is to engage cancer patient populations, those at risk of cancer, and organizations in rigorous studies focused on cancer control, prevention, treatment and care delivery.NCORP is a community-based research network that:Designs and conducts clinical trials and other human subject studies for adults and children in cancer control, prevention, screening, and care delivery, as well as quality-of-life studies embedded within treatment trials;Enhances patient and provider access to treatment and imaging trials conducted under the National Clinical Trials Network (NCTN);NCORP will support the following components that will be individually awarded through the respective Request for Applications (RFAs) indicated below:NCORP Research Bases (UG1 Clinical Trials Required)(covered by this NOFO);NCORP Community Sites (UG1 Clinical Trials Not Allowed); andNCORP Academic Community Sites (UG1 Clinical Trials Not Allowed).NCORP Research Bases will serve as the program's research hubs and are expected to:Provide an established organizational structure, with scientific and statistical leadership for developing, implementing, and analyzing multi-institutional cancer control, prevention, and care delivery (CCP&CD) clinical research, as well as quality-of-life studies embedded in treatment and imaging studies.Assume responsibility for study operations and data management, including efficient protocol development; compliance with Food and Drug Administration (FDA) and Office of Human Research Protections (OHRP) regulatory and participant protection requirements; auditing; training; quality assurance; and support to Community Sites and Academic Community Sites.Be based at institutions with comprehensive cancer clinical research expertise (e.g., NCI-designated Cancer Center, or healthcare research organization including NCI's National Clinical Trials Network (NCTN) Group Operations Centers, or a cancer foundation associated with a NCTN Group).
Posted: May 28, 2025, 12:00 a.m. EDT
Posted: May 28, 2025, 12:00 a.m. EDT
Posted: May 28, 2025, 12:00 a.m. EDT
Posted: May 28, 2025, 12:00 a.m. EDT
Background
The National Cancer Institute (NCI) Community Oncology Research Program (NCORP) aims to enhance the generalizability and dissemination of clinical trial results through accrual in community settings. The program focuses on engaging cancer patient populations and organizations in rigorous studies related to cancer control, prevention, treatment, and care delivery.

NCORP consists of a community-based research network that designs and conducts clinical trials for both adults and children, enhancing access to treatment and imaging trials under the National Clinical Trials Network (NCTN). This NOFO specifically addresses the NCORP Research Bases, which will serve as research hubs within the program.

Grant Details
NCORP Research Bases are expected to:
1. Provide an established organizational structure with scientific and statistical leadership for developing, implementing, and analyzing multi-institutional cancer control, prevention, and care delivery clinical research.
2. Assume responsibility for study operations and data management, ensuring compliance with FDA and OHRP regulations.
3. Support Community Sites and Academic Community Sites by providing training, quality assurance, auditing, and protocol development assistance.
4. Be based at institutions with comprehensive cancer clinical research expertise such as NCI-designated Cancer Centers or healthcare research organizations associated with NCTN Group Operations Centers.

Eligibility Requirements
Eligible applicants include higher education institutions (public/state controlled or private), nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), local/state/county governments, Indian/Native American tribal governments, federal agencies, public housing authorities, faith-based organizations, regional organizations, and independent school districts. Applications must be submitted by an NCI Clinical Trials Network Group or a cancer foundation affiliated with an NCTN Group.

Period of Performance
The project period is expected to last for six years.

Grant Value
The National Cancer Institute intends to commit $74.5 million in FY 2027 for up to seven awards.

Place of Performance
The grant will be performed at institutions with comprehensive cancer clinical research expertise located across various community settings.
Show All

Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.393 - Cancer Cause and Prevention Research
93.399 - Cancer Control
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 5/21/26 the National Institutes of Health posted grant opportunity RFA-CA-27-006 for NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required) with funding of $74.5 million. The grant will be issued under grant program 93.393 Cancer Cause and Prevention Research. It is expected that 7 total grants will be made.

Timing

Posted Date
May 21, 2026, 12:00 a.m. EDT
Closing Date
Sept. 18, 2026, 12:00 a.m. EDT Due in 103 Days
Last Updated
May 21, 2026, 10:30 a.m. EDT
Version
1
Archive Date
Nov. 18, 2026

Eligibility

Eligible Applicants
Public and State controlled institutions of higher education
City or township governments
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Special district governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Native American tribal governments (Federally recognized)
Independent school districts
State governments
Additional Info
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$74,500,000
Estimated Number of Grants
7

Contacts

Contact
National Institutes of Health
Contact Email
ncorp@mail.nih.gov
Contact Phone
(301) 402-2541

Documents

Posted documents for RFA-CA-27-006

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