Multi-Omics for Health and Disease - Data Analysis and Coordination Center (U01 Clinical Trial Not Allowed)

The goal of this Funding Opportunity Announcement (FOA) is to establish a Data Analysis and Coordination Center (DACC) that will be part of a collaborative initiative to advance the application of multi-omic technologies to study health and disease in diverse populations. Together with the Disease Study Sites (RFA-HG-22-008) and the Omics Production Center(s) (RFA-HG-22-009), the DACC will leverage clinical conditions where multi-omic approaches are expected to be most informative to: 1) explore the use of multi-omics, integrated with phenotypic and environmental exposure data, including social determinants of health (SDOH), to detect and assess molecular profiles associated with healthy and disease states; 2) develop generalizable data harmonization, integration, and analysis methods, as well as best practices and standards for the optimal application of multi-omics; and 3) create a multi-dimensional dataset that is available to the research community. The DACC will be primarily responsible for coordinating Consortium logistics, outreach, and dissemination of findings; for managing and securing Consortium data; for creating the multi-dimensional dataset; and for coordinating and contributing to consortium-wide protocol development, data analysis, and methods development efforts. While this program may provide some insights into disease etiology, its primary goal is to validate and enhance generalizable multi-omic approaches to identify meaningful biological changes related to health and disease.