Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)

Background
The Department of Health and Human Services, specifically the National Institutes of Health (NIH) and the National Institute on Minority Health and Health Disparities (NIMHD), is issuing a grant opportunity titled 'Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional).' The goal of the grant is to support research projects that test the effectiveness of multi-level interventions to prevent HIV in high-risk health disparity populations or subgroups in one or more geographic areas with a high rate of new HIV infections.

Grant Details
The initiative aims to further knowledge about reducing new HIV infections in the United States by implementing proven strategies to prevent new HIV infections, including use of pre-exposure prophylaxis (PrEP) by high-risk HIV-negative individuals and achieving an undetectable viral load through antiretroviral therapy (ART) in geographic hotspots with disproportionate numbers of new HIV infections. The initiative will support research projects that test the effectiveness of multi-level interventions to prevent HIV infection in high-risk health disparity populations or subpopulations in one or more geographic hotspots.

The interventions are expected to promote PrEP use, condom use, and HIV testing in HIV-negative individuals, encompass multiple domains and levels, use existing evidence-based HIV-prevention interventions or practices, be led by or conducted in partnership with clinicians and service providers responsible for delivering HIV prevention services or programs at the local, state, or regional level, emphasize intervention effectiveness, comparative effectiveness, success of intervention implementation strategies, or optimization of multi-component interventions, be tested with samples reflective of the diversity within the target population, and have potential for sustainability and scalability after the funded project is over.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits other than institutions of higher education, for-profit organizations, local governments, state governments, county governments, city or township governments, special district governments, Indian/Native American tribal governments (federally recognized), Indian/Native American tribal governments (other than federally recognized), U.S. Territory or Possession entities, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, and regional organizations. Foreign institutions are not eligible to apply. Eligible individuals with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) are invited to work with their organization to develop an application for support.

Period of Performance
The maximum project period is 5 years.

Grant Value
NIMHD intends to commit $5,000,000 in FY2023 to fund 5-6 awards. Application budgets are limited to $750,000 direct costs annually.