Molecular, Neural, and Cognitive Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders

The National Institute on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to encourage basic research on Non-Invasive Brain Stimulation (NIBS) using animal models. NIBS techniques such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound (tFUS) have emerged as promising approaches to treat addiction and substance use disorders (SUDs); however, their mechanisms of action are unclear, and this information would be useful to optimize treatment parameters. Research is encouraged to (1) elucidate molecular, cellular, and circuit level changes induced by NIBS protocols that have been found useful in human studies, and (2) identify molecular mechanisms and pathways by which NIBS techniques and protocols produce their therapeutic effects in SUDs. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into neuromodulation by non-invasive brain stimulation are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in non-invasive brain stimulation and substance use and addiction are encouraged, and these investigators should also begin considering applying for this application.