Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed)

Background
The National Institutes of Health (NIH) and its components, the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), are issuing a Notice of Funding Opportunity (NOFO) to support investigations into Mechanistic Investigations into ADRD Multiple Etiology Dementias. The goal is to identify cellular and molecular mechanisms of how and when multi-pathology interactions drive worsening ADRD pathophysiology and phenotypic outcomes, such as cognitive, behavioral, or functional impairment.

Grant Details
This NOFO supports investigations with a minimum of two Alzheimer's Disease-Related Dementias (ADRD) co-pathologies, with or without risk factors and co-morbidities, in the same model system to determine at a molecular level how ADRD-relevant co-pathologies causally accelerate disease progression and exacerbate phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream and downstream from aggregated protein states.

Eligibility Requirements
All organizations administering an eligible parent award may apply for a supplement under this NOFO. Eligible organizations include higher education institutions, nonprofits, for-profit organizations, state and local governments, federal agencies, U.S. territories or possessions, as well as faith-based or community-based organizations. Foreign organizations are not eligible to apply.

Period of Performance
The period of performance for the grant will begin on June 4, 2024. The project period is limited to five years.

Grant Value
NIH intends to commit a total budget of up to $4,500,000 per year to fund up to six awards for up to five years contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are limited to less than $500,000 direct costs per year.