Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings (R01 - Clinical Trial Not Allowed)

Background
The National Institutes of Health (NIH) and its components, the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), are offering a grant opportunity titled 'Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings (R01 - Clinical Trial Not Allowed)'. The grant aims to support studies proposing methodologies for in-cell structural biology to address mechanistic insights and causal cellular and molecular relationships between molecular pathology and Alzheimer's disease-related dementias (ADRD) clinical phenotypic outcomes.

Grant Details
The grant supports studies focusing on determining structures of ADRD-linked macromolecular in native (healthy and pathological) settings. The proposed methodology is expected to provide high-resolution information on the identity, dynamics, and relative abundance of macromolecular species associated with ADRD and how pathological environments influence dynamics and structural conformations.

Studies can also include the development of in situ research tools and resources to further characterize and validate the structural findings. The ultimate goal is for these structural studies in the native cellular environment to inform efficient tools development and designs that better identify and monitor the accumulation of dysfunctional proteins in patients, as well as for other diagnostic, treatment response, therapeutic development, and other related applications.

Eligibility Requirements
All organizations administering an eligible parent award may apply for a supplement under this NOFO. Eligible organizations include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, federal government agencies, U.S. territories or possessions, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, and regional organizations. Foreign organizations are not eligible to apply.

Period of Performance
The period of performance for the grant is up to five years. The earliest start date for the project is October 04, 2024.

Grant Value
NIH intends to commit a total budget of up to $3,000,000 per year to fund up to four awards for up to five years contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are limited to no more than $500,000 direct cost per year.