Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)

Background
The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes research translation), data management and analysis, community engagement, research experience and training coordination, and research support functions.

Grant Details
The scope of the SRP Centers is taken directly from the Superfund Amendments and Reauthorization Act of 1986, which includes advanced techniques for the detection, assessment, and evaluation of the effect on human health of hazardous substances; methods to assess the risks to human health presented by hazardous substances; methods and technologies to detect hazardous substances in the environment; and basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances. The grant supports problem-based, solution-oriented research incorporating responsiveness to mandates; problem-based, solution-oriented research; relevance to SRP and Superfund; innovation; and integration. The grant requires a minimum of two biomedical research (BMR) projects addressing biomedical or human health-related implications of hazardous substances, a minimum of two environmental science and engineering (ESE) projects addressing environmental science or engineering implications of hazardous substances, an Administrative Core, a Data Management and Analysis Core (DMAC), a Community Engagement Core (CEC), and a Research Experience and Training Coordination Core (RETCC). The grant also encourages innovative approaches such as high-throughput screening techniques, next generation sequencing, humanized models, tissue engineering, in silico modeling approaches, systems biology approaches for detection methods. It also emphasizes developing prevention and intervention strategies to improve human health by mitigating exposure and reducing toxicity of environmental contaminants.

Eligibility Requirements
Only one application per institution is allowed from Higher Education Institutions such as Public/State Controlled Institutions of Higher Education or Private Institutions of Higher Education. The eligibility is limited to accredited institutions of higher education.

Period of Performance
The project period can be up to 5 years with an earliest start date in October 2023. All applications are due by 5:00 PM local time of applicant organization.

Grant Value
NIEHS intends to fund up to approximately $25 million for fiscal year 2025 with an estimate of up to 12 awards. Applications may request a budget for direct costs of up to $2 million dollars for each year.