Limited Competition: Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)

Background
This Notice of Funding Opportunity (NOFO) invites applications for the continued support and advancement of the Mutant Mouse Resource and Research Centers (MMRRC). The MMRRC consortium is expected to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. A regional network of four MMRRCs and an Informatics, Coordination and Service Center (ICSC) collectively serve the needs of the biomedical research community for transgenic, knockout and other genetically-engineered mutant mice and related biomaterials.

MMRRC strains are held to the highest standards to optimize reproducibility of studies and assure scientific rigor and transparency; all submitted strains are thoroughly reviewed and documented and include additional quality control measures.

Grant Details
The MMRRC consortium is required to develop a small high risk, high return, research pilot project that complements the goals and needs of the MMRRC consortium. The U42 is a complex application, with an Overall Component that is the aggregate of the major 'Resource Section' Component and the minor 'Applied Research Section' Component. Each of these Components is described in Section IV.2.

The applied research component may comprise no more than 10 percent of the direct costs of the proposal. The U42-supported research that results in the generation of scientific data will occur as a result of the required Applied Research Component.

Eligibility Requirements
Only recipients previously funded under the auspices of RFA-OD-14-003 are eligible to apply.

Period of Performance
The total project period may not exceed five years.

Grant Value
ORIP intends to fund up to four awards, but the overall number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Requested Direct Costs must reflect actual needs of the project. For Renewal (a.k.a. Type 2) applications, no more than a 5 percent (direct cost) increase from the last non-competing year will be accepted.

Place of Performance
The Mutant Mouse Resource and Research Centers (MMRRC) are expected to serve biomedical researchers in the United States and worldwide.