Limited Competition: Human Pangenome Coordinating Center (U41) Clinical Trial Not Allowed

Background
The National Human Genome Research Institute (NHGRI) will renew the Human Genome Reference Program (HGRP). This FOA will establish the Human Pangenome Coordinating Center (HPCC), the central component of the HGRP. The HPCC will serve as the logistic and scientific coordinating center for the HGRP and will create, improve, release, and maintain new pangenome reference versions. The overall goal of the HGRP during the renewal is to produce a human pangenome reference that optimizes both the population genetic diversity represented, along with the utility for, and adoption by, the genomics research community.

This is a limited competition RFA. Only recipient organizations funded under RFA-HG-19-004 are eligible to apply.

Grant Details
The Coordinating Center will organize outreach efforts to international partners, researchers, and participant communities from diverse populations to create a globally inclusive pangenome resource. It will develop state-of-the-art, multi-use reference representations of the pangenome and work with other human reference groups to annotate, update, and maintain the pangenome for a broad user base including basic scientists and clinicians.

The Center will pilot the use of a new human pangenome reference by identifying and partnering with ongoing genomics consortia that will serve as early adopters of the pangenome and work with those groups on specific projects to determine the added scientific and clinical value of using the pangenome reference. Additionally, it will oversee logistical coordination of the HGRP by organizing meetings, tracking progress and publications, and establishing protocols and processes for communications and collaborations within and outside the consortium.

Eligibility Requirements
This is a limited competition RFA. Only recipient organizations funded under RFA-HG-19-004 are eligible to apply.

Period of Performance
The maximum project period is 5 years.

Grant Value
NHGRI intends to commit up to $3M in FY24 to fund one award.