Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Research Centers (U01 Clinical Trial Not Allowed)

This Limited Competition Funding Opportunity Announcement (FOA) invites applications from the Program Directors/Principal Investigators of the nine current Research Centers (RCs) of the Intestinal Stem Cell Consortium (ISCC) to submit collaborative projects to characterize the minimal, required niche factors that support intestinal stem cells in health and disease, using an integrated, multidisciplinary team science approach. The nine current RCs have been collaborating for the past 4 years, answering major questions in stem cell biology of the intestinal epithelium and also accelerating research by making information and resources available to the research community. In addition, the RCs have established effective and proficient collaborations with other RCs within the ISCC. The primary objective of this FOA is to continue advancing the understanding of intestinal epithelial stem cell biology with the ultimate goal of developing novel therapies targeting intestinal stem cells and supportive niche to regenerate and rebuild the human intestine.