Leveraging Data at Scale to Understand Natural Product Impacts on Whole Person Health (R01 Clinical Trial Not Allowed)

Background
The National Institutes of Health (NIH) and the National Center for Complementary and Integrative Health (NCCIH) are offering a grant opportunity to support the development, adaptation, and/or applications of computational tools to aggregate and analyze orthogonal chemical and/or biological data sets related to natural products. This initiative is part of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program, which aims to generate novel testable hypotheses regarding the biological activity and role of natural products in whole person health research.

Grant Details
The initiative aims to support transdisciplinary teams to adapt, develop, and/or deploy computational approaches to generate novel hypotheses regarding the whole person health effects of natural products. Projects must leverage and merge multiple compatible or interoperable sources and/or types of data. The use of artificial intelligence and machine learning approaches is encouraged. The supported efforts may include activities necessary to accomplish analyses, such as locating, verifying, and evaluating data sets and preparing them for semantic and computational interoperability.

The initiative requires the development of computational models that predict which combinations of natural products in a mixture are responsible for an observed activity. It also encourages improving approaches for integrating, mining, and analyzing natural product relevant health data from various sources.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, county governments, city or township governments, special district governments, Indian/Native American tribal governments (federally recognized), independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), foreign components of U.S. Organizations, and foreign organizations. Foreign organizations must follow policies described in the NIH Grants Policy Statement.

Period of Performance
The maximum project period is 5 years.
The open date for submission is May 28, 2024.
The earliest start date is June 28, 2024.

Grant Value
The National Center for Complementary & Integrative Health (NCCIH) intends to commit an estimated total of $800,000 to fund one award. Application budgets are limited to less than $500K in Direct Costs but need to reflect the actual needs of the proposed project.